依达拉奉右莰醇联合阿替普酶静脉溶栓治疗对超早期急性脑梗死患者神经功能及生活能力的影响

Effect of Edaravondalcohol with Rt-PA on Neurological Function and Life Ability in Patients with Ultra-early Acute Cerebral Infarction

目的 探究对超早期急性脑梗死患者行依达拉奉右莰醇联合阿替普酶静脉溶栓治疗的效果。方法 方便选取南京市江宁医院于2021年10月—2023年1月收治的112例超早期急性脑梗死患者为研究对象,利用红蓝球法分为对照组和观察组,每组56例。对照组患者实施阿替普酶静脉溶栓治疗,观察组患者在此基础上采用依达拉奉右莰醇治疗。对比两组患者神经功能、生活能力及不良事件发生情况。结果 观察组患者美国国立卫生院卒中量表(4.76±1.17)分、改良Rankin量表(1.16±0.32)分较对照组患者均更低,差异有统计学意义(t=7.780、3.884,P均<0.05);观察组患者生活能力指数评定中穿衣、进食、如厕、转移床椅能力评分较对照组患者均更高,差异有统计学意义(P均<0.05);观察组患者不良事件总发生率(1.79%)较对照组患者(12.50%)更低,差异有统计学意义(χ^(2)=4.846,P<0.05)。结论 对超早期急性脑梗死患者采用依达拉奉右莰醇联合阿替普酶静脉溶栓治疗有助于改善患者的神经功能,且患者的生活水平稳步改善。

Objective To explore the effect of edaravone dextrorphan combined with alteplase intravenous thromboly-sis in patients with ultra-early acute cerebral infarction.Methods A total of 112 patients with ultra-early acute cere-bral infarction admitted to Nanjing Jiangning Hospital from October 2021 to January 2023 were conveniently selected as the research objects.They were divided into control group and observation group by red and blue ball method,with 56 cases in each group.The patients in the control group were treated with alteplase intravenous thrombolysis,and the patients in the observation group were treated with edaravone dextrorphan on this basis.The neurological function,liv-ing ability and adverse events were compared between the two groups.Results The scores of National Institutes of Health Stroke Scale(4.76±1.17)points and Modified Rankin Scale(1.16±0.32)points in the observation group were lower than those in the control group,and the differences were statistically significant(t=7.780,3.884,both P<0.05);the scores of dressing,eating,toileting and transferring bed chair ability in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse events in the observation group(1.79%)was lower than that in the control group(12.50%),and the difference was sta-tistically significant(χ^(2)=4.846,P<0.05).Conclusion Edaravone dextrorphan combined with alteplase intravenous thrombolysis in patients with ultra-early acute cerebral infarction is helpful to improve the neurological function of pa-tients,and the living standard of patients is steadily improved.