结核抗体、结核感染T细胞斑点试验(T-SPOT.TB)及痰涂片、痰培养联合诊断活动性肺结核的实践价值

The Practical Value of Tuberculosis Antibodies,Tuberculosis Infection T Cell Spot Test(TSPOT.TB),Sputum Smear,and Sputum Culture in theCombined Diagnosis of Active Pulmonary Tuberculosis

文章探讨了结核抗体、结核感染T细胞斑点试验(T-SPOT.TB)及痰涂片、痰培养联合应用在活动性肺结核诊断中的临床实践价值。以2023年1月—12月期间甘肃医学院附属医院检验室接收的120例疑似肺结核患者样本为研究对象,对其血液和痰液样本进行检测,并评估单一检测结果与联合检测结果的诊断效能。研究结果显示,结核抗体、T-SPOT.TB、四种方法联合检测与临床检出结果无显著差异(P>0.05),痰涂片、痰培养检出阳性率显著低于临床检查结果(P<0.05)。四种方法联合检测的灵敏度和特异度分别为97.96%和95.45%,显著高于单一方法(P<0.05)。结核抗体、T-SPOT.TB及痰涂片、痰培养联合应用有助于提高活动性肺结核的诊断灵敏度,值得进一步推广应用。

This article has explored the clinical practice value of tuberculosis antibodies,tuberculosis infection T cell spot test(TSPOT.TB),sputum smear,and sputum culture combined in the diagnosis of active pulmonary tuberculosis.Taking 120 suspected pulmonary tuberculosis patient samples collected from the laboratory of Gansu Medical College from January 2023 to December 2023 as the research object,their lood and sputum samples were tested,and the diagnostic efficacy of single test results and joint test results were evaluated.The results showed that there was no difference(P>0.05)in the clinical results between the combined detection of tuberculosis antibodies,T-SPOT.TB and four methods,and the positive rate of sputum smear and sputum culture detection was lower than that of clinical examination results(P<0.05).The sensitivity and specificity of the combined detection of the four methods were 97.96%and 95.45%,which were significantly higher than those of a single method(P<0.05).The combined application of tuberculosis antibodies and T-SPOT.TB,sputum smear,and sputum culture can improve the diagnostic sensitivity of active pulmonary tuberculosis and is worth promoting.