双歧杆菌三联活菌胶囊联合阿托伐他汀钙、脂必泰治疗高脂血症患者的效果及对肠道菌群、内皮功能的影响

Effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules combined with atorvastatin calcium and Zhibitai in the treatment of patients with hyperlipidemia and its influences on intestinal flora and endothelial function

目的探讨双歧杆菌三联活菌胶囊联合阿托伐他汀钙、脂必泰治疗高脂血症患者的效果。方法选取2019年1月至2022年1月我院收治的100例高脂血症患者,以随机数字表法将其分为对照组和研究组,各50例。对照组给予阿托伐他汀钙联合脂必泰治疗,研究组在对照组基础上给予双歧杆菌三联活菌胶囊治疗。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的双歧杆菌、乳酸杆菌数量多于对照组,大肠杆菌、粪肠球菌数量少于对照组(P<0.05)。治疗后,研究组的一氧化氮(NO)水平高于对照组,内皮素-1(ET-1)水平低于对照组(P<0.05)。治疗后,研究组的脂蛋白(a)[Lp(a)]、载脂蛋白B100(ApoB100)水平低于对照组,颈动脉内膜中层厚度(IMT)小于对照组(P<0.05)。研究组的不良反应总发生率低于对照组(P<0.05)。结论双歧杆菌三联活菌胶囊联合阿托伐他汀钙、脂必泰治疗高脂血症患者的效果显著,可调节肠道菌群,改善内皮功能、脂代谢紊乱及IMT。

Objective To explore the effect of live combined Bifidobacterium,Lactobacillus and Enterococcus capsules combined with atorvastatin calcium and Zhibitai in the treatment of patients with hyperlipidemia.Methods A total of 100 patients with hyperlipidemia admitted in our hospital from January 2019 to January 2022 were selected and divided into control group and study group by random number table method,with 50 cases in each group.The control group was treated with atorvastatin calcium combined with Zhibitai,and the study group was treated with live combined Bifidobacterium,Lactobacillus and Enterococcus capsules on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the number of Bifidobacterium and Lactobacillus in the study group were more than those in the control group,and the number of Escherichiacoli and Enterococcusfaecalis were less than those in the control group(P<0.05).After treatment,the level of nitric oxide(NO)in the study group was higher than that in the control group,and the level of endothelin-1(ET-1)was lower than that in the control group(P<0.05).After treatment,the levels of lipoprotein(a)[Lp(a)]and apolipoprotein B100(ApoB100)in the study group were lower than those in the control group,and the carotid intima-media thickness(IMT)was smaller than that in the control group(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion Live combined Bifidobacterium,Lactobacillus and Enterococcus capsules combined with atorvastatin calcium and Zhibitai has a significant effect in the treatment of patients with hyperlipidemia,which can regulate intestinal flora,improve endothelial function,lipid metabolism disorder and IMT.