Temperature-feedback two-photon-responsive metal-organic frameworks for efficient photothermal therapy

温度反馈指导的双光子金属有机框架材料及其高效光热治疗

The realization of real-time thermal feedback for monitoring photothermal therapy(PTT)under near-infrared(NIR)light irradiation is of great interest and challenge for antitumor therapy.Herein,by assembling highly efficient photothermal conversion gold nanorods and a temperature-responsive probe((E)-4-(4-(diethylamino)styryl)-1-methylpyridin-1-ium,PyS)within MOF-199,an intelligent nanoplatform(AMPP)was fabricated for simultaneous chemodynamic therapy and NIR light-induced temperature-feedback PTT.The fluorescence intensity and temperature of the PyS probe are linearly related due to the restriction of the rotation of the characteristic monomethine bridge.Moreover,the copper ions resulting from the degradation of MOF-199 in an acidic microenvironment can convert H_(2)O_(2)into•OH,resulting in tumor ablation through a Fenton-like reaction,and this process can be accelerated by increasing the temperature.This study establishes a feasible platform for fabricating highly sensitive temperature sensors for efficient temperature-feedback PTT.

实现近红外光热治疗过程的实时温度监控,是肿瘤治疗中的一个重要挑战。本研究通过在MOF-199中组装高光热转换效率的金纳米棒和温度响应型探针PyS,制备了一种智能纳米平台(AMPP)。其中,探针PyS由于其特征烯桥键旋转或限制,双光子荧光与温度变化呈线性关系。与此同时,MOF-199在酸性微环境中降解产生的铜离子能够将H_(2)O_(2)转化为•OH,通过类芬顿反应导致肿瘤消融,且该过程可被光热进一步促进。综上,AMPP可以同时实现化学动力治疗以及温度反馈指导的近红外光热治疗,为高效肿瘤治疗提供了一种新材料、新方法。