Rho/ROCK信号通路在糖尿病视网膜病变中的研究进展

Research progress of Rho/ROCK signaling pathway in diabetes retinopathy

糖尿病视网膜病变(diabetic retinopathy,DR)是导致劳动年龄人群视力障碍的重要原因,其复杂的发病机制尚未完全明确。虽然一些新兴治疗方法在DR的治疗中取得显著疗效,但仍存在治疗效果欠佳及并发症等问题。Rho GTP酶是一种小分子蛋白,通过激活下游蛋白ROCK参与细胞骨架调节等多种细胞活动。在DR发病过程中Rho/ROCK信号通路被激活,抑制Rho/ROCK信号传导可能抑制DR的进展。本文从炎症、新生血管、血-视网膜屏障(blood retinal barrier,BRB)、晚期糖基化终末产物(advanced glycation end products,AGEs)、糖尿病视网膜神经变性(diabetic retinal neurodegeneration,DRN)等方面阐述Rho/ROCK信号通路在DR发病机制中的研究进展,以期为DR的治疗提供新思路。

Diabetic retinopathy(DR)is an important cause of visual impairment in working-age people,and its complex pathogenesis has not been fully understood.Although some emerging treatment methods have achieved significant results in the treatment of DR,there are still some problems with poor treatment effects and complications.RhoGTPase is a small molecule protein that participates in various cellular activities such as cytoskeleton regulation by activating the downstream protein ROCK.During the pathogenesis of DR,the Rho/ROCK signaling pathway is activated,and inhibiting Rho/ROCK signaling may inhibit the progression of DR.This article explains the Rho/ROCK signal from the aspects of inflammation、neovascularization、blood-retinal barrier(BRB)、advanced glycation end products(AGEs),and diabetic retinal neurodegeneration(DRN).The research progress of pathways in the pathogenesis of DR is expected to provide new ideas for the treatment of DR.