雷火灸治疗气虚型结直肠癌患者癌因性疲乏的临床研究

Clinical Study on the Treatment of Cancer-Related Fatigue in Qi Deficiency-Type Colorectal Cancer Patients Using Thunder-Fire Moxibustion

目的:探究雷火灸治疗气虚型结直肠癌患者癌因性疲乏的临床疗效。方法:选取2022年2月—2023年8月溧阳市中医医院接收的96例结直肠癌患者,随机数字法分为常规组和雷火灸组,每组48例。常规组给予常规治疗,雷火灸组在常规组的基础上给予雷火灸治疗。比较两组治疗后的临床疗效和治疗前后癌因性疲乏、中医证候积分、生存质量、C反应蛋白(CRP)、促肾上腺皮质激素(ACTH)、皮质醇(CORT)及不良反应。结果:治疗14 d后,雷火灸组患者的总有效率为97.9%(47/48),高于常规组的85.4%(41/48),差异有统计学意义(P<0.05)。治疗14 d后,两组的PFS-R评分中认知、情感、感觉、行为4个维度的评分均降低(P<0.05),且雷火灸组低于常规组(P<0.05)。治疗14 d后,两组的气短、乏力、神疲、自汗、懒言积分均降低(P<0.05),且雷火灸组低于常规组(P<0.05)。两组治疗前与治疗3、7、14 d比较差异有统计学意义(P<0.05);治疗3、7、14 d雷火灸组的KPS评分高于常规组(P<0.05)。治疗14 d后,两组的CRP、ACTH均降低,CORT均升高(P<0.05);且雷火灸组的CRP、ACTH低于常规组,CORT高于常规组(P<0.05)。治疗14 d后,雷火灸组的不良反应情况优于常规组(P<0.05)。结论:雷火灸治疗气虚型结直肠癌患者癌因性疲乏的临床疗效较为显著。

Objective:To investigate the clinical efficacy of Thunder-Fire Moxibustion in treating cancer-related fatigue in Qi deficiency-type colorectal cancer patients.Methods:A total of 96 colorectal cancer patients who were admitted to Liyang Traditional Chinese Medicine Hospital from February 2022 to August 2023 were selected.They were randomly divided into two groups using random number methods:the Conventional Treatment Group and the Thunder-Fire Moxibustion Group,with 48 patients in each group.The Conventional Treatment Group received standard treatment,while the Thunder-Fire Moxibustion Group received Thunder-Fire Moxibustion in addition to the standard treatment.The clinical efficacy and changes in cancer-related fatigue,traditional Chinese medicine syndrome scores,quality of life,C-reactive protein(CRP),adrenocorticotropic hormone(ACTH),cortisol(CORT),and adverse reactions were compared between the two groups.Results:After 14 days of treatment,the total effective rate in the Thunder-Fire Moxibustion Group(97.9%)was higher than that in the Conventional Treatment Group(85.4%),and the difference was statistically significant(P<0.05).After 14 days,the PFS-R scores for cognition,emotion,sensation,and behavior dimensions decreased in both groups(P<0.05),with the Thunder-Fire Moxibustion Group showing lower scores than the Conventional Treatment Group(P<0.05).The scores for shortness of breath,fatigue,weakness,spontaneous sweating,and reluctance to speak decreased in both groups(P<0.05)after 14 days,with the Thunder-Fire Moxibustion Group showing lower scores than the Conventional Treatment Group(P<0.05).The differences between pre-treatment and the scores at 3,7,and 14 days were statistically significant(P<0.05).The KPS scores in the Thunder-Fire Moxibustion Group were higher than those in the Conventional Treatment Group at 3,7,and 14 days(P<0.05).After 14 days of treatment,both groups showed a decrease in CRP and ACTH,and an increase in CORT(P<0.05).The CRP and ACTH levels in the Thunder-Fire Moxibustion Group were lower than those in the Conventional Treatment Group,while CORT was higher(P<0.05).The Thunder-Fire Moxibustion Group also had fewer adverse reactions compared to the Conventional Treatment Group(P<0.05).Conclusion:Thunder-Fire Moxibustion demonstrates significant clinical efficacy in treating cancer-related fatigue in Qi deficiency-type colorectal cancer patients.