双歧杆菌四联活菌片联合标准四联疗法治疗Hp感染消化性溃疡的效果及安全性

Efficacy and Safety of Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live Combined with Standard Quadruple Therapy in the Treatment of Peptic Ulcer with Hp Infection

目的:观察幽门螺杆菌(Hp)感染消化性溃疡患者在标准四联疗法基础上加用双歧杆菌四联活菌片的治疗效果与安全性。方法:选择2021年6月—2023年5月北京市仁和医院消化内科接收的180例Hp感染消化性溃疡患者,按随机数字表法分为对照组(n=90,给予标准四联疗法)、观察组(n=90,给予标准四联疗法联合双歧杆菌四联活菌片)。比较两组溃疡愈合优良率、Hp清除率、胃肠功能[胃动素(MTL)、D-乳酸(D-LA)、生长抑素(SS)]、炎症因子[白介素-10(IL-10)、基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)]、不良反应、复发率。结果:观察组溃疡愈合优良率、Hp清除率均较对照组高,差异均有统计学意义(P<0.05)。治疗前,两组胃肠功能、炎症因子比较,差异均无统计学意义(P>0.05);治疗后,两组MTL、D-LA、MMP-9、TNF-α均降低,IL-10、SS均升高,且观察组MTL、D-LA、MMP-9、TNF-α均较对照组低,IL-10、SS均较对照组高,差异均有统计学意义(P<0.05)。观察组不良反应与对照组比较,差异无统计学意义(P>0.05)。观察组复发率较对照组低,差异有统计学意义(P<0.05)。结论:Hp感染消化性溃疡给予标准四联疗法联合双歧杆菌四联活菌片治疗,能够提高Hp清除率,加快溃疡愈合进程,改善胃肠功能,减轻炎症反应,降低远期复发风险,且安全性高。

Objective:To observe the therapeutic effect and safety of adding Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live in the basis of standard quadruple therapy in patients with peptic ulcer with helicobacter pylori(Hp)infection.Method:A total of 180 patients with peptic ulcer with Hp infection admitted to Department of Gastroenterology,Beijing Renhe Hospital from June 2021 to May 2023 were selected and divided into control group(n=90,given standard quadruple therapy)and observation group(n=90,given standard quadruple therapy combined with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live)according to random number table method.The excellent and good rate of ulcer healing,Hp clearance rate,gastrointestinal function[motilin(MTL),D-lactic acid(D-LA),somatostatin(SS)],inflammatory factors[interleukin-10(IL-10),matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α)],adverse reactions and recurrence rate were compared between two groups.Result:The excellent and good rate of ulcer healing and Hp clearance rate in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in gastrointestinal function and inflammatory factors between two groups(P>0.05).After treatment,MTL,D-LA,MMP-9 and TNF-αin both groups were decreased,IL-10 and SS were increased,and MTL,D-LA,MMP-9 and TNF-αin the observation group were lower than those in the control group,IL-10 and SS were higher than those in the control group,the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between observation group and control group(P>0.05).The recurrence rate of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Standard quadruple therapy combined with Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus Cereus Tablets,Live for peptic ulcer with Hp infection can improve Hp clearance rate,accelerate ulcer healing process,improve gastrointestinal function,reduce inflammatory response,and reduce the risk of long-term recurrence,with high safety.