重组人生长激素辅助治疗对高龄不孕IVF⁃ET患者血清FSH、E_(2)及LH水平的影响

Effect of recombinant human growth hormone adjuvant therapy on serum FSH,E_(2) and LH levels in elderly infertile IVF⁃ET patients

目的探讨在实施体外受精⁃胚胎移植(IVF⁃ET)治疗过程中使用重组人生长激素(rhGH)辅助治疗对高龄不孕症女性患者血清卵泡刺激素(FSH)、雌二醇(E_(2))及促黄体生成素(LH)水平的影响。方法回顾性选取2021年1月至2023年8月邯郸市中心医院收治的高龄不孕女性102例,依据治疗方案分为对照组[予促性腺激素释放激素(GnRH)拮抗剂方案治疗,n=50]、试验组(予GnRH拮抗剂方案+rhGH辅助治疗方案,n=52);比较两组促排卵结果、性激素水平(FSH、E_(2)、LH)、妊娠结局及不良反应情况。结果试验组Gn总用量、Gn使用天数比对照组少,差异有统计学意义(P<0.05);试验组获卵总个数、可移植胚胎数及优质胚胎数比对照组高,但差异无统计学意义(P>0.05)。两组治疗后的FSH、E_(2)、LH水平均下降,且试验组治疗后的FSH、E_(2)、LH水平均低于对照组,差异有统计学意义(P<0.05)。试验组治疗后取消周期率、流产率低于对照组,临床妊娠率、活产率高于对照组,但差异无统计学意义(P>0.05)。试验组、对照组不良反应发生率比较差异无统计学意义(P>0.05)。结论相较于GnRH拮抗剂方案单独治疗,GnRH拮抗剂+rhGH辅助治疗方案可进一步调节高龄不孕女性FSH、LH、E_(2)水平,提高获卵数、优胚率及临床妊娠率。

Objective To investigate the effect of recombinant human growth hormone(rhGH)adjuvant therapy on serum follicle stimulating hormone(FSH),estradiol(E_(2))and luteinizing hormone(LH)levels in elderly infertile women during in vitro fertilization and embryo transfer(IVF⁃ET).Methods In this study,a retrospective analysis method was used to select 102 elderly infertile women admitted to Handan Central Hospital from January 2021 to August 2023.According to the treatment plan,they were divided into a control group treated with a gonadotropin⁃releasing hormone(GnRH)antagonist regimen,n=50 and the experimental group treated with GnRH antagonist regimen+rhGH adjuvant therapy,n=52.The results of ovulation induction,sex hormone levels(FSH,E_(2),LH),pregnancy outcomes and adverse reactions were compared between the two groups.Results The total dosage of Gn and the number of days of Gn use in the experimental group were less than those in the control group,and the difference was statistically significant(P<0.05).The total number of oocytes retrieved,the number of transplantable embryos and the number of high⁃quality embryos in the experimental group were higher than those in the control group,but the difference was not statistically significant(P>0.05).The levels of FSH,E_(2)and LH in the two groups decreased after treatment,with the levels in the experimental group being lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the cycle cancellation rate and abortion rate in the experimental group were lower than those in the control group,and the clinical pregnancy rate and live birth rate were higher than those in the control group,but the differences were not statistically significant(P>0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(P>0.05).Conclusion Compared to the GnRH⁃a regimen alone,the GnRH⁃a+rhGH adjuvant regimen can significantly regulate the levels of FSH,LH,and E_(2)in women with advanced infertility.It also improves the number of eggs obtained,the rate of eugenic embryos,and the rate of clinical pregnancy.