丁苯酞注射液联合阿替普酶静脉溶栓治疗急性脑梗死的临床效果

Clinical Efficacy of Butylphthalide Injection Combined with Alteplase Intravenous Thrombolysis in the Treatment of Acute Cerebral Infarction

目的探讨急性脑梗死(ACI)采用丁苯酞注射液联合阿替普酶(rt-PA)静脉溶栓治疗的临床效果。方法选取2019年1月至2023年12月本院收治的80例ACI患者,以随机数字表法分成研究组(n=40)与对照组(n=40),对照组给予rt-PA静脉溶栓,研究组给予丁苯酞注射液与rt-PA静脉溶栓联合治疗,比较两组临床疗效、血液流变学、脑血流灌注量、不良反应发生率。结果研究组治疗有效率(97.50%)高于对照组(80.00%),差异有统计学意义(P<0.05);两组治疗后全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)水平下降,且研究组HSV、LSV、PSV水平低于对照组,差异有统计学意义(P<0.05);两组治疗后脑血容量(CBV)、脑血流量(CBF)升高,平均通过时间(MTT)缩短,且研究组CBV、CBF水平高于对照组,MTT短于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率(7.50%)与对照组(12.50%)比较差异无统计学意义(P>0.05)。结论丁苯酞注射液与rt-PA静脉溶栓联合应用于ACI患者治疗中,能够提升临床疗效,改善血液流变学,增加脑血流灌注量,安全性较高。

Objective To explore the clinical efficacy of butylphthalide injection combined with alteplase(rt-PA)intravenous thrombolysis in the treatment of acute cerebral infarction(ACI).Methods Eighty patients with ACI admitted to our hospital from January 2019 to December 2023 were randomly divided into a study group(n=40)and a control group(n=40)using a random number table.The control group received rt-PA intravenous thrombolysis,while the study group received butylphthalide injection combined with rt-PA intravenous thrombolysis.The clinical efficacy,hemorheology,cerebral blood flow perfusion,and incidence of adverse reactions were compared between the two groups.Results The treatment efficacy in the study group(97.50%)was higher than that in the control group(80.00%),with statistically significant differences(P<0.05).After treatment,the levels of whole blood high shear viscosity(HSV),whole blood low shear viscosity(LSV),and plasma viscosity(PSV)decreased in both groups,and the levels in the study group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the cerebral blood volume(CBV)and cerebral blood flow(CBF)increased,and the mean transit time(MTT)shortened in both groups.The CBV and CBF levels in the study group were higher than those in the control group,and the MTT was shorter,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the study group(7.50%)and the control group(12.50%)(P>0.05).Conclusion The combination of butylphthalide injection and rt-PA intravenous thrombolysis in the treatment of ACI can improve clinical efficacy,enhance hemorheology,increase cerebral blood flow perfusion,and has a high safety profile.