光生物调节疗法在骨关节炎治疗中的研究进展

Research Progress of Photobiomodulation Therapy in Osteoarthritis

光生物调节疗法(PBMT)是一种根据不同治疗目的将生物组织暴露于特定波长光源的光疗法,长期应用于口腔科学、皮肤病学、骨科学等领域。在骨关节炎(OA)治疗中,大量的临床实践和基础医学研究已经证实,PBMT作为一种物理治疗方法,能够有效减轻OA患者的疼痛,促进炎症因子的代谢和清除,显著增强组织的修复能力,并加快不同组织和神经的再生,为OA患者提供了崭新的治疗选择。然而,PBMT的操作方式和剂量控制尚未形成统一的标准,治疗效果的评估具有一定的主观性和不确定性,仍存在较大的研究空间。尽管已有一些文章探讨了PBMT在OA领域的研究现状,但其主要是通过PBMT对OA的治疗讨论PBMT在抗炎方面的作用,而忽略了OA作为一种涉及全关节组织疾病的整体性和PBMT对OA作用效果的复杂性。本文系统梳理了PBMT在OA非手术治疗和手术治疗中的应用,分析了PBMT在OA整体治疗中的局限性,特别关注了PBMT在实际操作中存在的问题,深入思考了其未来的发展趋势,为充分利用PBMT无创、无痛和无副作用的特性发展先进的OA治疗手段与医疗器械提供了参考。

Photobiomodulation therapy(PBMT)is a kind of light therapy that exposes biological tissue to a specific wavelength light source according to different therapeutic purposes,and has been used in stomatology,dermatology,osteology and other fields for a long time.In the treatment of osteoarthritis(OA),a large number of clinical practices and basic medical researches have confirmed that PBMT,as a physical therapy,can effectively reduce the pain of patients with OA,promote the metabolism and clearance of inflammatory factors,significantly enhance the repair ability of tissues,and accelerate the regeneration of different tissues and nerves,providing a new treatment option for patients with OA.However,the specific operation and dose control of PBMT in practical applications have not yet formed a unified standard,and the evaluation of therapeutic effect is subjective and uncertain,and there is still a large space for exploration.Although a number of review articles have explored this aspect,the anti-inflammatory effects of PBMT are mainly discussed through the treatment of OA with PBMT,ignoring the holistic nature of OA as a disease involving whole joint tissues and the complexity of the effects of PBMT on OA.This paper system-atically reviews the application of PBMT in the non-surgical and surgical treatment of OA,considers the limitations of PBMT in the overall treatment of OA,pays special attention to the problems existing in the actual operation of PBMT,and analyzes in depth the future development trend,so as to provide references for the development of advanced OA treatment methods and medical devices by making full use of the characteristics of PBMT,which are non-invasive,painless and without side effects.