Shared diagnostic genes and potential mechanisms between COVID-19 and sepsis revealed by bioinformatics analysis

The coronavirus disease 2019(COVID-19)pandemic,triggered by the novel coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has ravaged the globe,resulting in a staggering loss of life and wreaking havoc on the worldwide economy.[1,2]Sepsis is a cascade of abnormal responses provoked by infection,leading to a critical deterioration in organ function that poses a life-threatening risk.[3]However,it is unclear from published reports whether COVID-19 and sepsis are commonly aff ected by molecular factors.Therefore,we performed a bioinformatics analysis to uncover shared diagnostic genes and potential mechanisms between COVID-19 and sepsis.