放射性核素碘-131治疗甲状腺功能亢进症的临床价值分析

Analysis of the Clinical Value of Radionuclide Iodine 131 in the Treatment of Hyperthyroidism

目的:探讨放射性核素碘-131在甲状腺功能亢进症(简称甲亢)治疗中的应用价值。方法:选取2021年1月—2023年12月就诊于昆山市第一人民医院的甲亢患者78例作为研究对象,随机分为对照组(应用甲巯咪唑片治疗)和研究组(应用放射性核素碘-131治疗),各39例。比较两组治疗效果、治疗前后血清甲状腺激素水平、不良反应发生率。结果:研究组总有效率高于对照组,差异有统计学意义(P=0.009);治疗后,两组血清促甲状腺激素水平高于治疗前,三碘甲状腺原氨酸、血清甲状腺素、游离三碘甲状腺原氨酸、血清游离甲状腺激素水平低于治疗前,研究组改善效果优于对照组(P<0.05);研究组不良反应发生率低于对照组,差异有统计学意义(P=0.017)。结论:应用放射性核素碘-131治疗甲亢,可提高患者治疗有效率,改善血清甲状腺激素水平,降低不良反应发生率,利于患者康复。

Objective:To explore the application value of radionuclide iodine 131 in the treatment of hyperthyroidism(hyperthyroidism for short).Methods:Seventy-eight cases of hyperthyroidism patients who visited Kunshan First People's Hospital from January 2021 to December 2023 were selected as the study subjects,and randomly divided into the control group(application of methimazole tablets treatment)and the study group(application of radionuclide iodine-131 treatment),with thirty-nine cases in each group.Compare the treatment effect,serum thyroid hormone level before and after treatment,and the incidence of adverse reactions in the two groups.Results:The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P=0.009);after treatment,the serum thyroid-stimulating hormone levels of the two groups were higher than those before treatment,and the levels of triiodothyronine,serum thyroxine,free triiodothyronine,and serum free thyroid hormone were lower than those before treatment,and the improvement effect of the study group was superior to that of the control group(P<0.05);the incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P=0.017).Conclusion:The application of radionuclide iodine-131 in the treatment of hyperthyroidism can improve the effective rate of treatment,improve the serum thyroid hormone level,reduce the incidence of adverse reactions,and facilitate the recovery of patients.