经颅交流电刺激治疗认知障碍的作用参数及机制的研究进展

Research progress on the parameters and mechanism of transcranial alternating current stimulation in the treatment of cognitive impairment

认知是人类最基本的心理过程,是大脑的高级神经功能。各种神经精神疾病导致的认知功能障碍可能涉及工作记忆、注意、执行功能等一个或多个认知领域,严重影响患者的生存质量。经颅交流电刺激(tACS)可以直接调节大脑皮质振荡以及内在振荡活动,从而影响感觉、知觉和认知过程。本文基于循证医学方法,对国内外tACS应用于认知障碍的研究进行分析和总结,以期为今后tACS在认知障碍中的科学应用提供理论依据。

Cognition is the most basic human mental process,and is a higher neural function of the brain.Cognitive dysfunction caused by various neuropsychiatric diseases may involve one or more cognitive domains such as working memory,attention and executive function,which can seriously affect the quality of patients'survival.Transcranial alternating current stimulation(tACS)can directly modulate cortical oscillations as well as intrinsic oscillatory activity,thereby affecting sensory,perceptual and cognitive processes.This paper analyses and summarizes domestic and international studies on tACS applied to cognitive disorders based on evidence-based medicine methods,to provide the theoretical basis for future scientific application of tACS in cognitive disorders.