特布他林联合布地奈德治疗支气管哮喘合并肺炎支原体感染的临床效果

Clinical effectiveness of combining terbutaline with budesonide for the treatment of bronchial asthma complicated by mycoplasma pneumoniae infection

目的观察特布他林联合布地奈德治疗支气管哮喘合并肺炎支原体感染的临床效果。方法选取2020年1月—2022年1月汉川市妇幼保健院收治的支气管哮喘合并肺炎支原体感染患儿98例,采用随机数字表法分为观察组和对照组,各49例。在常规治疗基础上,对照组予吸入用布地奈德混悬液治疗,观察组在对照组基础上加予硫酸特布他林雾化吸入用溶液治疗,2组均治疗2周。比较2组患儿治疗效果,治疗前后肺功能指标[第1秒用力呼气容积(FEV 1)、用力肺活量(FVC)、呼气流量峰值(PEF)]变化,辅助性T17细胞(Th17)、调节性T细胞(Treg)水平以及炎性因子[干扰素-γ(IFN-γ)、白介素-2(IL-2)、白介素-4(IL-4)]水平。结果观察组患者治疗总有效率为93.88%,高于对照组的73.47%(χ^(2)=7.470,P=0.006);治疗2周后,2组FEV 1、FVC、PEF均较治疗前升高,Treg细胞水平上升,Th17细胞水平与IFN-γ、IL-2、IL-4水平均较治疗前下降,且观察组变化幅度大于对照组(P均<0.01)。结论特布他林联合布地奈德治疗支气管哮喘合并肺炎支原体感染的效果肯定,可显著改善患儿的肺功能,提高患儿免疫力。

Objective To observe the clinical effects of combining terbutaline with budesonide for the treatment of bronchial asthma complicated by mycoplasma pneumoniae infection.Methods From January 2020 to January 2022,a total of 98 cases of children with bronchial asthma complicated by mycoplasma pneumoniae infection,admitted to Hanchuan Maternal and Child Health Hospital were selected.They were divided into the observation group and the control group using a random number table method,with 49 cases in each group.On the basis of conventional treatment,the control group received treatment with budesonide suspension for inhalation,while the observation group received additional treatment with terbutaline sulfate nebulizer solution in addition to the control group.Both groups of children were treated for 2 weeks.The treatment effects were compared between the two groups of children,as well as the changes in lung function indicators(FEV 1,FVC,PEF),levels of Th17 and Treg cells,and levels of inflammatory cytokines(IFN-γ,IL-2,IL-4)before and after treatment.Results The total effective rate of treatment in the observation group was 93.88%,which was higher than the control group′s 73.47%(χ^(2)=7.470,P=0.006).After 2 weeks of treatment,both groups showed an increase in FEV 1,FVC and PEF compared to before treatment.The Treg cell levels increased,while the Th17 cell levels,as well as the levels of IFN-γ,IL-2 and IL-4,decreased compared to before treatment.Furthermore,the observed changes in the observation group were greater than those in the control group(P<0.01).Conclusion The clinical effectiveness of combining terbutaline with budesonide for the treatment of bronchial asthma complicated by mycoplasma pneumoniae infection is positive.It can significantly improve lung function in children and enhance their immune response.