调脾护心方治疗稳定性冠心病的疗效及对心率变异性的影响

The Effect of Tiaopi Huxin Formula on Stable Coronary Heart Disease and Heart Rate Variability

目的:观察调脾护心方治疗稳定性冠心病的临床疗效及对病人心率变异性(HRV)的影响。方法:选取2022年1月—2024年4月于安徽中医药大学第一附属医院心内科收治入院的稳定性冠心病病人60例,依据入院时间依次排序后进行随机抽样分组法,分为对照组和观察组,每组30例。观察组予以常规西药治疗加调脾护心方口服,对照组予以常规西药治疗,连续用药4周。比较两组临床疗效、心绞痛发作次数及持续时间、HRV相关指标、不良反应发生率。结果:观察组治疗后临床疗效总有效率为85.71%,高于对照组的67.86%,差异有统计学意义(P<0.05)。两组治疗后心绞痛发作次数较治疗前有不同程度减少,持续时间有不同程度缩短,且观察组改善程度更为显著(P<0.05);两组治疗后HRV相关指标较治疗前有不同程度升高,且观察组升高更为显著(P<0.05)。治疗过程中两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:调脾护心方可以缓解稳定性冠心病病人心绞痛症状,改善HRV指标,且安全性较好。

Objective:To investigate the clinical efficacy of Tiaopi Huxin Formula for the treatment of stable coronary heart disease and its effect on heart rate variability(HRV).Methods:A total of 60 patients with stable coronary heart disease,who were admitted to the Department of Cardiology at the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2022 to April 2024,were selected.According to their admission time,they were randomly divided into control group and observation group,with 30 cases in each group.The patients in observation group were treated with conventional western medicine and oral administration of Tiaopi Huxin Formula,and the patients in control group were treated with conventional western medicine.After 4 weeks of treatment,the clinical efficacy,the frequency and duration of angina pectoris attack,HRV related indexes,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 85.71%,which was significantly higher than that of the control group(67.86%,P<0.05).After treatment,the frequency of angina pectoris attacks reduced,and the duration was shortened to varying degrees,the improvement in the that in observation group was significantly more significant(P<0.05).After treatment,the HRV related indexes of the two groups were higher than those before treatment,and the that in observation group increased more significantly(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion:Tiaopi Huxin Formula can relieve symptoms of angina pectoris in patients with stable coronary heart disease,improve HRV indexes,and with better safety.