立体定向手术治疗脑胶质瘤患者的疗效及其对血清泛素偶联酶2C、CXC趋化因子配体10水平的影响

Efficacy of stereotactic surgery for patients with brain glioma and its impact on serum levels of ubiquitin conjugating enzyme 2C and CXC chemokine ligand 10

目的分析立体定向手术治疗脑胶质瘤患者的疗效及其对血清泛素偶联酶2C(UBE2C)、CXC趋化因子配体10(CXCL10)水平的影响。方法收集2018年1月至2023年2月新乡医学院第三附属医院收治的45例脑胶质瘤患者的临床资料,依照手术方式不同分为2组,对照组22例接受传统开颅手术治疗,观察组23例接受立体定向手术治疗,比较2组疗效、术后1 a生存率、术前及术后6个月神经功能[神经功能缺损程度量表(NIHSS)]、免疫细胞[辅助性T细胞(Th)1、Th2、Th17]、生活能力[Barthel指数(BI)]以及血清UBE2C、CXCL10、炎症细胞因子[肿瘤坏死因子-α(TNF-α)、白介素-17(IL-17)、IL-2、IL-6]水平。结果观察组总有效率(100.00%)高于对照组(72.73%;χ^(2)=5.070,P=0.024);观察组术后1 a生存率(86.96%)高于对照组(54.55%;χ^(2)=5.750,P=0.017)。术后6个月,观察组NIHSS评分低于对照组,而BI评分高于对照组(t=6.728,P<0.001;t=5.339,P<0.001);观察组Th1高于对照组,而Th2、Th17均低于对照组(t=3.793,P<0.001;t=4.691,P<0.001;t=5.293,P<0.001);观察组血清UBE2C、CXCL10、TNF-α、IL-17、IL-2、IL-6水平均低于对照组(t=8.778,P<0.001;t=3.543,P=0.001;t=9.831,P<0.001;t=11.148,P<0.001;t=11.516,P<0.001;t=10.954,P<0.001)。结论立体定向手术治疗脑胶质瘤的效果显著,能有效改善患者神经功能、免疫功能、生活能力,抑制炎症细胞因子、UBE2C、CXCL10表达,延长患者生存。

Objective To analyze the efficacy of stereotactic surgery for patients with brain glioma and its impact on serum levels of ubiquitin conjugating enzyme 2C(UBE2C)and CXC chemokine ligand 10(CXCL10).Methods The clinical data of 45 patients with glioma in the Third Affiliated Hospital of Xinxiang Medical University from January 2018 to February 2023 were collected,they were divided into two groups according to different surgical methods:22 cases of the control group received traditional craniotomy treatment,and 23 cases of the observation group received stereotactic surgery treatment.The efficacy and 1-year survival rate were compared between the two groups,as well as the levels of neurological function[neurological impairment severity scale(NIHSS)],immune cells[T helper cell(Th)1,Th2,Th17],life ability[Barthel index(BI)],serum ubiquitin-conjugating enzyme 2C(UBE2C),CXC chemokine ligand 10(CXCL10)and inflammatory cell factors[tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),IL-2,IL-6]levels before and 6-month after operation.Results The total effective rate of the observation group(100.00%)was higher than that of the control group(72.73%;χ^(2)=5.070,P=0.024);the 1-year survival rate of the observation group(86.96%)was higher than that of the control group(54.55%;χ^(2)=5.750,P=0.017).Six months after surgery,the NIHSS score of the observation group was lower than that of the control group,and the BI score was higher than that of the control group(t=6.728,P<0.001;t=5.339,P<0.001).Six months after surgery,the Th1 level in the observation group was higher than that in the control group,while the Th2 and Th17 levels were lower than those in the control group(t=3.793,P<0.001;t=4.691,P<0.001;t=5.293,P<0.001).Six months after surgery,the serum levels of UBE2C,CXCL10,TNF-α,IL-17,IL-2 and IL-6 in the observation group were lower than those in the control group(t=8.778,P<0.001;t=3.543,P=0.001;t=9.831,P<0.001;t=11.148,P<0.001;t=11.516,P<0.001;t=10.954,P<0.001).Conclusion Stereotactic surgery for the treatment of brain glioma has significant effects,which can effectively improve patients’neurological function,immune function and living ability,inhibit the expression of serum inflammatory cytokines,UBE2C and CXCL10,and improve survival.