靶向淋巴细胞治疗系统性红斑狼疮的研究进展

Latest research progress in lymphocyte-targeted treatment of systemic lupus erythematosus

系统性红斑狼疮(SLE)是一种在组织和器官中表现出高度异质性的自身免疫性疾病,其发病原因目前尚不明确。淋巴细胞是参与SLE发生发展的重要免疫细胞。已有研究认为T细胞、B细胞的异常激活是SLE发病的重要原因之一。本文通过总结T细胞、B细胞在SLE发病机制中的作用,以及靶向T细胞、B细胞治疗SLE相关研究的新进展,为研究SLE的发病机制以及开发治疗SLE的新型药物提供重要的科学依据。

Systemic lupus erythematosus(SLE)is an autoimmune disease with high heterogeneity in tissues and organs,Whose pathogenesis is still unclear.Lymphocytes are important immune cells involved in the occurrence and development of SLE.It has been found that the abnormal activation of T cells and B cells are important causes of SLE.In this review,by summarizing the role of T cells and B cells in the pathogenesis of SLE and the latest research progress in lymphocyte-targeted treatment strategy of SLE,the important scientific evidences can be provided to the study of the pathogenesis of SLE and the development of new medicines for the treatment of SLE.