拟除虫菊酯杀虫剂暴露对儿童健康的影响

Effects of pyrethroid insecticide exposure on children's health

拟除虫菊酯类杀虫剂(pyrethroid insecticides,PYR)作为一种高效、低毒且易降解的广谱杀虫剂,自20世纪70年代以来广泛地应用于农林畜牧和家庭害虫防治.然而随着研究的深入,其对儿童的潜在危害也逐渐暴露.本文总结了国内外儿童因该农药暴露产生相关疾病的流行病学调查,发现其可能降低儿童的智力水平和行为能力,改变儿童的生长发育,及损伤机体的免疫功能;又通过分析相关动物实验及细胞实验,归纳了其对儿童神经、发育、免疫系统的影响及作用机制,为实验室深入研究提供科学依据,为临床治疗给予合理的指导,也为研发无害化杀虫剂给予参考思路.

Pyrethroid insecticides(PYR),as a commonly used insecticide with high efficiency,low toxicity and biodegradation,has been widely used in agriculture,forestry,livestock and household pest control since 1970s.However,with further research,more attention has been paid to its potential harm to children.This article summarized domestic and foreign environmentally epidemiological investigation on pyrethroids associated with children’s health,and found that it may reduce the intelligence level and behavioral ability,change the growth and development of children,and damage the immune function of the body.This article also reviewed the effects and mechanism of its action on children's nervous system,reproductive system and immune system.The study provided scientific basis for further laboratory research,reasonable guidance for clinical treatment and reference idea for the invention of harmless insecticides.