微反应器合成2-氯-4-氟-5-硝基苯甲醛

Synthesis of 2-chloro-4-fluoro-5-nitrobenzaldehydeby microreactor

采用微反应器合成2-氯-4-氟-5-硝基苯甲醛最佳工艺为硝酸与硫酸质量比为1∶11,反应温度为40℃,苯甲醛硫酸混合溶液最佳流速为38 g/min,硝硫混酸最佳流速为41 g/min,2-氯-4-氟-5-硝基苯甲醛含量为99.5%以上。

The optimal process for the synthesis of 2-chloro-4-fluoro-5-nitrobenzaldehyde by microreactor was as follows,the mass ratio of nitric acid to sulfuric acid was 1∶11,the reaction temperature was 40℃,the optimal flow rate of benzaldehyde-sulfuric acid mixed solution was 38 g/min,the optimal flow rate of nitro-sulfuric acid mixed solution was 41 g/min,and the content of 2-chloro-4-fluoro-5-nitrobenzaldehyde was more than 99.5%.