更昔洛韦联合雾化重组人干扰素α1b治疗对呼吸道合胞病毒感染肺炎患儿炎症因子及免疫功能的影响

Effect of Ganciclovir Combined with Nebulized Recombinant Human Interferonα1b on Inflammatory Factors and Immune Function in Children with Respiratory Syncytial Virus-Infected Pneumonia

目的:分析更昔洛韦联合雾化重组人干扰素α1b治疗对呼吸道合胞病毒感染肺炎患儿炎症因子及免疫功能的影响。方法:选取本院收治的呼吸道合胞病毒感染肺炎患儿100例作为研究对象。根据随机数表法分为对照和观察两组,各50例;比较两组治疗前、后的炎性因子降钙素原(PCT)、白介素-6(IL-6)、C反应蛋白(CRP)与免疫球蛋白IgA、IgG、IgM水平,详细记录症状体征消失时间并分析治疗期间发生的不良症状。结果:治疗后两组比较,观察组持续发热、咳嗽、憋喘以及肺啰音消失时间短(P<0.05),血清PCT、IL-6与CRP水平低(P<0.05),血清IgG、IgA、IgM水平明显升高(P<0.05);治疗期间,两组恶心呕吐、白细胞降低、皮疹的总发生率比较无统计学意义(P>0.05)。结论:对呼吸道合胞病毒感染肺炎患儿实施更昔洛韦联合雾化重组人干扰素α1b联合用药可缩短症状体征消失时间,减轻机体炎症反应,提高机体免疫力,安全性相对较好。

Objective:To analyze the effects of ganciclovir combined with nebulized recombinant human interferonα1b on inflammatory factors and immune function in children with respiratory syncytial virus(RSV)-infected pneumonia.Methods:A total of 100 children with RSV-infected pneumonia admitted to our hospital were selected as study subjects.They were divided into a control group and an observation group according to the random number table method,with 50 cases in each group.The levels of inflammatory factors including procalcitonin(PCT),interleukin-6(IL-6),C-reactive protein(CRP),and immunoglobulin IgA,IgG,IgM were compared between the two groups before and after treatment.The time for disappearance of symptoms and signs was recorded in detail,and adverse symptoms during treatment were analyzed.Results:After treatment,the observation group had shorter durations of persistent fever,cough,dyspnea,and lung rales compared with the control group(P<0.05).The serum levels of PCT,IL-6,and CRP were lower in the observation group(P<0.05),while the serum levels of IgG,IgA,and IgM were significantly higher(P<0.05).During treatment,there was no statistically significant difference in the total incidence of nausea,vomiting,leukopenia,and rash between the two groups(P>0.05).Conclusion:The combined use of ganciclovir and nebulized recombinant human interferonα1b in children with RSV-infected pneumonia can shorten the duration of symptoms and signs,reduce inflammatory reactions,improve immune function,and have relatively good safety.