氨茶碱联合沙美特罗替卡松治疗老年支气管哮喘的临床效果

Clinical Effect of Aminophylline Combined with Salmeterol Xinafoate and Fluticasone Propionate in Treatment of Elderly Bronchial Asthma

目的:分析氨茶碱联合沙美特罗替卡松治疗老年支气管哮喘的临床效果。方法:选取2021年1月—2022年12月上海市浦东新区东明社区卫生服务中心收治的老年支气管哮喘患者94例为观察对象,通过奇偶分组法分为两组,各47例。对照组采用沙美特罗替卡松治疗,观察组在对照组基础上采用氨茶碱治疗。比较两组临床疗效、肺功能指标、实验室指标。结果:观察组治疗总有效率为95.74%,高于对照组(80.85%),差异有统计学意义(P=0.025)。治疗前,两组第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、呼气峰值流速(PEF)对比,差异无统计学意义(P>0.05);治疗后,两组FEV_(1)、FVC、PEF水平均升高,且观察组高于对照组(P<0.05)。治疗前,两组免疫球蛋白E(IgE)、白细胞介素-6(IL-6)、肿瘤坏死因子(TNF-α)和神经生长因子(NGF)水平对比,差异无统计学意义(P>0.05);治疗后,两组IgE、IL-6、TNF-α和NGF水平均明显降低,且观察组低于对照组(P<0.05)。结论:氨茶碱联合沙美特罗替卡松治疗老年支气管哮喘的临床效果显著,能够提升患者肺功能,减轻炎性反应。

Objective:To analyze the clinical effect of aminophylline combined with salmeterol xinafoate and fluticasone propionate in the treatment of elderly bronchial asthma.Methods:A total of 94 elderly patients with bronchial asthma who were admitted to Shanghai Pudong New Area Dongming Community Health Service Center from January 2021 to December 2022 were selected as the observation subjects.Using the odd-even grouping method,the patients were divided into two groups,with 47 cases in each group.The control group was treated with salmeterol xinafoate and fluticasone propionate,and the observation group was treated with aminophylline on the basis of the observation group.The clinical efficacy,pulmonary function index,and laboratory index were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.74%,which was higher than that in the control group(80.85%),and the difference was statistically significant(P=0.025).Before treatment,there was no significant difference in forced expiratory volume in 1 s(FEV_(1)),forced vital capacity(FVC)and peak expiratory flow rate(PEF)between the two groups(P>0.05).After treatment,the levels of FEV_(1),FVC and PEF in the two groups increased,and the levels in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of immunoglobulin E(IgE),interleukin-6(IL-6),tumor necrosis factor(TNF-α)and nerve growth factor(NGF)between the two groups(P>0.05).After treatment,the levels of IgE,IL-6,TNF-αand NGF in the two groups were significantly reduced,and the levels in the observation group were lower than those in the control group(P<0.05).Conclusion:Aminophylline combined with salmeterol xinafoate and fluticasone propionate has significant clinical effects in the treatment of elderly bronchial asthma,and can improve lung function and relieve inflammatory reaction.