营养支持治疗对头颈部肿瘤放疗患者的营养状态及营养干预效果的前瞻性研究

Nutritional intervention effect of nutritional support therapy on head and neck tumor radiotherapy patients

目的观察营养支持治疗对头颈部肿瘤放疗患者的营养状态影响及营养干预效果。方法选择于我科2020年1月至2021年12月治疗的100例头颈部肿瘤放疗患者为本次研究对象,随机分为对照组(常规饮食指导)与试验组(常规饮食指导上开展营养支持治疗),各50例,比较2组患者治疗效果。结果相较于放疗前,2组患者放疗后同一时刻营养指标、淋巴细胞亚群数值、生活质量量表评分(QLQ-C30)均降低,但试验组放疗后上述指标降幅均低于同一时刻对照组(P<0.05。相较于放疗前,2组患者放疗后主观全面评定量表PG-SGA)均降低且试验组放疗后PG-SGA高于同一时刻对照组(P<0.05)。试验组患者放疗治疗后副损伤发生率均低于对照组(P<0.05)。随访2年,试验组总生存期以及无病生存期均高于对照组(P<0.05)。结论头颈部肿瘤放疗患者营养支持治疗可有效改善其营养状态。

Objective To observe the effect of nutritional intervention on patients with head and neck tumor treated by nutritional support therapy.Methods One hundred patients with radiotherapy for head and neck tumors treated in our department from January 2020 to December 2021 were selected as the subjects.They were randomly divided into a control group(conventional diet guidance)and an experimental group(nutritional support treatment on conventional diet guidance),50 cases in each group,and the therapeutic effects of the two groups were compared.Results Compared with the indexes before radiotherapy,the nutritional indexes,lymphocyte subsets,and Quality of Life scale score(QLQ-C30)of the two groups all decreased at the same time after radiotherapy,but the decreases of the above indexes in the experimental group were lower than those in the control group at the same time(P<0.05).Compared with the indexes before radiotherapy,the subjective Comprehensive Rating Scale(PG-SGA)after radiotherapy was decreased in both groups,and PG-SGA after radiotherapy in the experimental group was significantly higher than that in the control group at the same time(P<0.05).The incidence of collateral injury in the experimental group was lower than that in the control group(P<0.05).After 2 years of follow-up,the overall survival and disease-free survival of the experimental group were higher than those of the control group(P<0.05).Conclusion Nutritional support therapy can effectively improve the nutritional status of patients with head and neck tumor radiotherapy.