基于RhoA/ROCK信号通路探讨中药干预缺血性脑卒中的研究进展

Research progress on traditional Chinese herbal medicine interventions in ischemic stroke through RhoA/ROCK signaling pathway

基于Ras同源基因家族成员A/Rho相关卷曲螺旋激酶(RhoA/ROCK)信号通路综述中药干预缺血性脑卒中的研究进展。RhoA/ROCK信号通路在缺血性脑卒中的病理过程中发挥着重要作用,主要涉及细胞凋亡、兴奋性毒性、神经炎症、血脑屏障和神经功能等方面。部分中药复方及其活性成分可以通过调控RhoA/ROCK信号通路及上下游靶基因的表达,起到减少神经元凋亡、减轻炎症反应、减小脑梗死面积、保护血脑屏障、促进突触修复和再生等作用,为中药治疗缺血性脑卒中后续作用机制的研究及治疗新靶点的开发提供新思路。

This review discusses the advancements in research on interventions using traditional Chinese herbal medicine(TCHM)for ischemic stroke through the RhoA/Rho-associated coiled-coil containing protein kinase(ROCK)signaling pathway.The RhoA/ROCK pathway plays a crucial role in the pathological process of ischemic stroke,primarily involving cellular apoptosis,excitotoxicity,neuroinflammation,the blood-brain barrier,and neural function.Various TCHM compound formulas and its active ingredients regulate the RhoA/ROCK signaling pathway and the expression of its upstream and downstream target genes to reduce neuronal apoptosis,alleviate inflammatory responses,decrease the size of cerebral infarctions,protect the blood-brain barrier,and promote synaptic repair and regeneration.These findings provide new insights for the study of mechanisms underlying TCHM treatments for ischemic stroke and the development of novel therapeutic targets.