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T2DM合并高血压患者Fetuin B、CysC水平及临床意义分析

Analysis of Fetuin B,Cystatin C levels and their clinical significance in patients with type 2 diabetes mellitus complicated with hypertension
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摘要 目的探讨胎球蛋白(Fetuin)B、胱抑素C(Cys C)在2型糖尿病(T2DM)合并高血压(HBP)患者中的临床意义。方法选择2020年8月至2021年12月该院收治的T2DM患者125例,根据是否合并HBP将其分为T2DM组(53例)、T2DM合并HBP组(72例)。纳入45例单纯HBP患者作为对照组。采用酶联免疫吸附试验检测3组患者血清Fetuin B、Cys C水平。比较不同血压分级T2DM合并HBP患者血清Fetuin B、Cys C水平。绘制受试者工作特征(ROC)曲线,分析Fetuin B、Cys C对T2DM合并HBP的诊断价值。采用二元Logistic回归分析T2DM合并HBP的影响因素。结果与对照组相比,T2DM组、T2DM合并HBP组Fetuin B、Cys C水平均明显升高(P<0.05);与T2DM组相比,T2DM合并HBP组Fetuin B、Cys C水平均明显升高(P<0.05)。Fetuin B、Cys C水平随血压分级升高而升高(P<0.05)。Fetuin B>19.65 ng/mL、Cys C>1.386 mg/L是T2DM合并HBP的危险因素(P<0.05),Fetuin B、Cys C在诊断T2DM合并HBP中的曲线下面积分别为0.846、0.784。结论Fetuin B、Cys C在T2DM合并HBP患者血液中的水平呈异常高表达,且其水平随血压升高而升高,在T2DM合并HBP诊断及血压分级中均具有一定价值。 Objective To investigate the clinical significance of Fetuin B and Cystatin C(Cys C)in patients with type 2 diabetes mellitus(T2DM)complicated with hypertension(HBP).Methods A total of 125 patients with T2DM admitted to the hospital from August 2020 to December 2021 were selected and divided into the T2DM group(53 cases)and the T2DM complicated with HBP group(72 cases)based on the presence of hypertension.An additional 45 patients with isolated HBP were included as the control group.Serum levels of Fetuin B and Cys C were detected in all three groups using enzyme-linked immunosorbent assay.The levels of Fetuin B and Cys C were compared among T2DM patients with different hypertension grades.Receiver operating characteristic(ROC)curve was plotted to assess the diagnostic value of Fetuin B and Cys C in T2DM patients complicated with HBP.Binary Logistic regression analysis was performed to identify factors influencing T2DM complicated with HBP.Results Compared with the control group,the levels of fetuin B and Cys C in the T2DM group and the T2DM complicated with HBP group increased significantly(P<0.05).Compared with the T2DM group,the levels of fetuin B and Cys C in the T2DM complicated with HBP group increased significantly(P<0.05).Fetuin B and Cys C levels increased with the severity of hypertension(P<0.05).Fetuin B>19.65 ng/mL and Cys C>1.386 mg/L were risk factors for T2DM complicated with HBP(P<0.05).The area under the curve(AUC)for Fetuin B and Cys C in diagnosing T2DM complicated with HBP were 0.846 and 0.784 respectively.Conclusion Fetuin B and Cys C are abnormally highly expressed in the blood of patients with T2DM complicated with HBP,and their levels increase with the rise of blood pressure,which is valuable in the diagnosis of T2DM complicated with HBP and in the grading of blood pressure.
作者 庞雅平 韩梅 董帅 贾春利 姜兰叶 PANG Yaping;HAN Mei;DONG Shuai;JIA Chunli;JIANG Lanye(Department of Endocrinology,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Operating Room,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Emergency,the Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075000,China)
出处 《检验医学与临床》 CAS 2024年第21期3152-3156,共5页 Laboratory Medicine and Clinic
基金 河北省张家口市科学技术局课题(2121188D)。
关键词 胎球蛋白B 胱抑素C 2型糖尿病 高血压 影响因素 Fetuin B Cystatin C type 2 diabetes mellitus hypertension risk factor
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