血清IP-10、SOCS1联合T-SPOT.TB对肺结核的诊断价值

Diagnostic value of serum IP-10 and SOCS1 combined with T-SPOT.TB for pulmonary tuberculosis

目的探讨γ-干扰素诱导蛋白10(IP-10)、细胞因子信号转导抑制物1(SOCS1)在肺结核(PTB)患者血清中的表达,以及IP-10、SOCS1联合结核感染T细胞斑点试验(T-SPOT.TB)对PTB的诊断价值。方法收集2020年1月至2023年2月在该院治疗的96例PTB患者作为PTB组,另选取同期该院收治的与PTB患者临床资料基本一致的其他肺部疾病患者96例作为对照组。比较两组血清IP-10和SOCS1水平。采用受试者工作特征(ROC)曲线分析血清IP-10、SOCS1对PTB的诊断效能。采用四格表法分析血清IP-10、SOCS1联合T-SPOT.TB对PTB的诊断价值。结果与对照组相比,PTB组血清IP-10水平明显升高(P<0.05),SOCS1水平明显降低(P<0.05)。四格表法分析结果显示,血清IP-10、SOCS1联合T-SPOT.TB诊断PTB的准确率为92.71%,灵敏度为95.83%,特异度为89.58%。其中3项联合诊断的特异度高于IP-10、SOCS1单独诊断(P<0.05),准确率和灵敏度高于T-SPOT.TB、IP-10、SOCS1单独诊断(P<0.05)。结论PTB患者血清IP-10水平明显升高,SOCS1水平明显降低,血清IP-10、SOCS1联合T-SPOT.TB对PTB具有较高的诊断价值。

Objective To investigate the expression ofγ-interferon-induced protein 10(IP-10)and suppressor of cytokine signaling 1(SOCS1)in the serum of patients with pulmonary tuberculosis(PTB),and the diagnostic value of IP-10,SOCS1 combined with the tuberculosis-specific T-cell spot test(T-SPOT.TB)for PTB.Methods A total of 96 patients with PTB treated at the hospital from January 2020 to February 2023 were selected as the PTB group.Simultaneously,96 patients with other pulmonary diseases,whose clinical data were similar to those of the PTB patients in the hospital,were chosen as the control group.The levels of serum IP-10 and SOCS1 were compared between the two groups.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of serum IP-10 and SOCS1 for PTB.The diagnostic value of combining ser um IP-10,SOCS1 and T-SPOT.TB for PTB was evaluated by a contingency table analysis.Results Compared wi th the control group,the level of serum IP-10 in the PTB group was significantly higher(P<0.05);the level of SOCS1 was significantly lower(P<0.05).The contingency table analysis showed that the combination of serum IP-10,SOCS1 and T-SPOT.TB for diagnosing PTB had an accuracy of 92.71%,sensitivity of 95.83%and specificity of 89.58%.The specificity of the combined diagnosis of IP-10,SOCS1 and T-SPOT.TB was higher than that of IP-10 or SOCS1 alone(P<0.05),and the accuracy and sensitivity were higher than those of T-SPOT.TB,IP-10 or SOCS1 alone(P<0.05).Conclusion In PTB patients,serum IP-10 level is significantly elevated,while SOCS1 level is significantly decreased.The combination of serum IP-10,SOCS1 and T-SPOT.TB provides a high diagnostic value for PTB.