HBsAg单试剂反应性献血者的复检情况及相关影响因素分析

Analysis of the rescreening of blood donors with single-reagent reactive HBsAg results and related influencing factors

目的探讨乙型肝炎病毒表面抗原(HBsAg)单试剂反应性献血者的复检情况及相关影响因素。方法选取2022年6月至2023年3月衡水市中心血站180例HBsAg单试剂反应性献血者作为研究对象,献血者均在献血后6个月后进行复检,对其复检结果进行分析,并探讨影响复检结果的因素。结果180例HBsAg单试剂反应性献血者中,6个月后复检有144例献血者酶联免疫吸附试验(ELISA)和病毒核酸检测(NAT)检测均为阴性,复检合格,合格率为80.00%;其他36例献血者ELISA、NAT复检结果中存在任意一项阳性,复检不合格。复检合格与复检不合格的献血者在性别、献血次数、初检A值、是否固定献血方面比较,差异均有统计学意义(P<0.05),在年龄、婚姻状态、学历、职业方面比较,差异均无统计学意义(P>0.05)。多因素Logistic回归分析结果显示,献血次数、初检A值及固定献血均会影响献血者复检结果(P<0.05)。结论HBsAg单试剂反应性献血者6个月后复检合格率较高,其复检结果与献血次数、初检A值及固定献血情况存在关系,该研究可以帮助HBsAg单试剂反应性献血者归队检测,减少献血者的流失。

Objective To investigate the rescreening results and related influencing factors of blood donors with single-reagent reactive results for hepatitis B surface antigen(HBsAg).Methods A total of 180 blood donors with single-reagent reactive results for HBsAg,who donated blood at Hengshui Central Blood Station from June 2022 to March 2023,were selected as the study subjects.All donors underwent rescreening six months after blood donation.The rescreening results were analyzed,and the factors influencing rescreening results were investigated.Results Among the 180 blood donors with single-reagent reactive results for HBsAg,144 donors were found to be negative by both enzyme-linked immunosorbent assay(ELISA)and nucleic acid testing(NAT)during rescreening six months later,resulting in a pass rate of 80.00%.The remaining 36 donors had positive results in either ELISA or NAT,and their rescreening was deemed unsuccessful.There were statistically significant differences between the successful and unsuccessful rescreening blood donors in terms of gender,number of donations,initial test A values,and whether they were regular blood donors(P<0.05).However,there were no statistically significant differences in age,marital status,education level,or occupation between the successful and successful rescreening blood donors(P>0.05).Multivariate Logistic regression analysis showed that the number of donations,initial test A values and regular blood donation significantly influenced the rescreening outcomes(P<0.05).Conclusion The rescreening pass rate of blood donors with single-reagent reactive results for HBsAg after six months is relatively high.The rescreening outcomes are associated with the number of donations,initial test A values and regular donation status.This study can aid in re-integrating donors with single-reagent reactive results into the donor pool,thereby reducing donor loss.