血清CA125、CA724、CEA水平与胃癌临床病理特征的关系研究

Study on the Relationship Between Serum CA125,CA724 and CEA Levels and Clinicopathologic Characteristics of Gastric Cancer

目的探讨血清糖类抗原(CA)125、CA724、癌胚抗原(CEA)水平与胃癌(GC)患者临床病理特征的关系。方法选取80例GC患者作为观察组,另选取同期80例胃部良性病变患者作为对照组。检测并比较两组患者血清CA125、CA724、CEA水平及其阳性检出率,并分析GC患者血清CA125、CA724、CEA水平与其临床病理特征的关系。结果观察组CA125、CA724、CEA水平及其阳性检出率均明显高于对照组(P<0.05);且TNM分期为Ⅲ~Ⅳ期、分化程度低、浸润深度在黏膜下层以及有淋巴结转移的GC患者血清CA125、CA724、CEA水平均明显增高,差异均具有统计学意义(P<0.05)。结论CA125、CA724、CEA在GC中呈高表达状态,且与TNM分期、分化程度、浸润深度和淋巴结转移关系密切,可为GC患者病情发展的进一步评估提供有力的参考,也可作为GC预后的评估指标。

Objective To investigate the relationship between serum glycan antigen(CA)125,CA724,and carcinoembryonic antigen(CEA)levels and clinicopathologic features of gastric cancer(GC)patients.Methods Eighty patients with GC were selected as the observation group,and another 80 patients with benign gastric lesions in the same period were selected as the control group.The serum CA125,CA724 and CEA levels and their positive detection rates were detected and compared between the 2 groups,and the relationship between the serum CA125,CA724 and CEA levels of GC patients and their clinicopathological features was analyzed.Results The levels of CA125,CA724,CEA and their positive detection rates in the observation group were significantly higher than those in the control group(P<0.05);and the serum levels of CA125,CA724 and CEA were significantly higher in the GC patients with TNM stageⅢ~Ⅳ,a low degree of differentiation,an infiltration depth in the submucosal layer,and lymph node metastasis,and the differences were all statistically significant(P<0.05).Conclusion CA125,CA724,and CEA were highly expressed in GC and were closely related to TNM stage,degree of differentiation,depth of infiltration,and lymph node metastasis,which can provide a powerful reference for further assessment of disease progression in GC patients and can be used as a prognostic indicator for GC.