南通市首例B群流行性脑脊髓膜炎病例报道

A Case Report of The First Case of Serogroup B Meningococcal Meningitis in Nantong

目的:对南通市首例B群流行性脑脊髓膜炎(以下简称流脑)病例进行报告分析。方法:对2022年2月南通大学附属医院报告的1例实验室确诊流脑病例开展流行病学调查,采集病例血液和脑脊液标本进行脑膜炎奈瑟菌分离培养、血清群PCR鉴定及药物敏感性试验。结果:该病例为26岁女性,自述既往接种过流脑疫苗,接种记录不详,无流脑病例接触史,无续发病例出现。从该病例的血液标本中分离培养出脑膜炎奈瑟菌,经鉴定为脑膜炎奈瑟菌B群;菌株对氨苄西林、头孢噻肟、氯霉素、米诺环素、利福平、左氧氟沙星敏感,对复方新诺明耐药。结论:该病例为南通市报告的首例B群流脑,提示南通市流行菌群可能发生变迁,B群流脑有流行风险,应加强流脑病原学监测。

OBJECTIVE To report and analyze the first case of serogroup B meningococcal meningitis in Nantong.METHODS An epidemiological investigation was carried out on a laboratory-confirmed case of cerebrospinal meningitis reported by the Affiliated Hospital of Nantong University in 2022.Blood and cerebrospinal fluid samples were collected for isolation and culture of Neisseria meningitidis,serum group PCR identification and drug sensitivity test.RESULTS The case was a 26-year-old female who reported that she had been vaccinated with the meningococcal vaccine in the past,and the vaccination record was unknown.There was no contact history of meningococcal meningitis cases,and there were no secondary cases occurred.Neisseria meningitidis was isolated and cultured from the blood sample,and was identified as Neisseria meningitidis serogroup B;the strain was sensitive to ampicillin,cefotaxime,chloramphenicol,minocycline,rifampicin,levofloxacin,and resistant to compound sulfamethoxazole.CONCLUSION The case is the first case of serogroup B meningococcal meningitis reported in Nantong,suggesting that the epidemic flora in Nantong may change,and serogroup B meningococcal meningitis has the risk of epidemic,and the pathogenic surveillance should be strengthened.