摘要
Gastric cancer remains a significant global health challenge,causing a substantial number of cancer-related deaths,particularly in China.While the exact causes of gastric cancer are still being investigated,Helicobac-ter pylori(H.pylori)infection has been identified as the primary risk factor,which triggers chronic inflammation and a multistage progression of gastric lesions that may lead to carcinogenesis over a long latency time.Since the 1990s,numerous efforts have focused on assessing the effectiveness of H.pylori eradication in preventing new cases of gastric cancer among both the general population and patients who have undergone early-stage cancer treatment.This body of work,including several community-based interventions and meta-analyses,has shown a reduction in both the incidence of and mortality from gastric cancer following H.pylori treatment,alongside a decreased risk of metachronous gastric cancer.In this review,we seek to consolidate current knowledge on the effects of H.pylori treatment on gastric cancer prevention,its systemic consequences,cost-effectiveness,and the influence of antibiotic resistance and host characteristics on treatment outcomes.We further discuss the potential for precision primary prevention of H.pylori treatment and comment on the efficient implementation of test-and-treat policies and allocation of health resources towards minimizing the burden of gastric cancer globally.
基金
supported by the National Natural Science Founda-tion of China(grant number:82273704)
the Beijing Hospitals Author-ity Clinical Medicine Development of Special Funding Support(grant number:ZLRK202325)
Beijing Hospitals Authority’s Ascent Plan,Na-tional Key R&D Program of China(grant number:2018YFA0507503)
Peking University Medicine Fund for world’s leading discipline or disci-pline cluster development(grant number:BMU2022XKQ004)
Science Foundation of Peking University Cancer Hospital(grant number:2022-27)and Science Foundation of Peking University Cancer Hospital(grant number:XKFZ2410)
he funding sources had no role in study design
in the collection,analysis,and interpretation of data
in the writing of the report
or in the decision to submit the article for publication.The funders had no role in study design,data collection,data analysis,data interpretation,or writing of the report.
