西比灵对大鼠高血压性脑血管病变作用的研究

Study on treatment effect of Sibelium to cerebral vascular lesion of hypertension

目的 探讨西比灵对大鼠高血压性脑血管病变的作用及其机制。方法 建立肾血管性高血压大鼠 (RHR)模型 ,用插胃管法喂食西比灵对RHR进行治疗 ,观察动脉血压、脑血流速度和脑血管形态的改变。结果 用药 2～ 4周动脉血压明显低于同期未用药RHR ,4～ 6周后脑底动脉内腔面积、横断面积、中膜厚度等明显好于未用药RHR ,这些作用可以持续 2～ 4周。结论 在高血压早期 ,西比灵可以降低RHR的动脉血压 。

Objective To probe into the treatment effect of Sibelium to hypertensive cerebral vascular lesion and its mechanism.Methods After preparing the model of renovascular hypertensive rats (RHR), we observed the changes of the arterial blood pressure, the cerebral blood velocity, and the pathology of cerebral vascular with treatment of Sibelium. Results The arterial blood pressure of the rats taking medicine 2 to 4 weeks later was lower obviously than RHR of no taking medicine at the same stage, The pathological changes of basal cerebral arteries in the rats were milder than RHR of no taking medicine after treating 4 to 6 weeks. These effects may keep 2 to 4 weeks.Conclusion At early stage of hypertension,Sibelium can reduce the arterial blood pressure of RHR, and stop the progress of cerebral vascular lesion.