前列腺癌组织MVD、DNA倍体与其临床生物学行为的研究

Microvascular density and DNA ploidy in carcinoma of prostate in relation to clinic-biological behavior

目的 探讨前列腺癌DNA倍体、微血管密度 (MVD)与癌分级、临床分期及预后的关系。方法 应用计算机图像分析技术、免疫组织化学 (SP)法 ,测定 30例前列腺癌 (PC)、30例前列腺增生症 (BPH)细胞核DNA倍体、MVD的变化。结果 随癌分化程度降低 ,DNA倍体增加 ,MVD升高 ,其差异有显著性 (P<0 .0 1) ;临床分期处于C、D期DNA倍体MVD高于A、B期者 (P <0 .0 1) ,其生存率亦变低 (P <0 .0 5 )。结论 DNA倍体、MVD可准确地反映PC的预后。DNA倍体与MVD间呈正相关关系。

Objective To determine the relationship between these biologic markers and tumor grade and stage and prognosis of the carcinoma.Methods 30 cases of prostatic carcinoma (PC)and 30 cases of benign prostatic hyperplasia (BPH) were studied on DNA ploidy and microvascular density (MVD) with computer assisted image analysis and immunohistochemistry (SP).Results The DNA pliody and MVD were increased along with decreasing of the tumor histological grading.The ploidy was significantly different among PC4 PC3 PC2 PC1and BPH ( P <0.01),MVD( P <0.01),and stage of invasive MVD DNA ploidy (C.D) were higher than region (A.B)prostatic carcinoma ( P <0.01).The survival rate is decreased( P <0.05). Conclusion MVD is a accurate predictor in the evaluation of the prognosis of prostatic carcinoma. DNA ploidy and MVD were positively correlated with each other in prostatic carcinoma.