Liguzinediol对阿霉素诱导的慢性心衰大鼠心功能的影响

Effects of Liguzinediol on Hemodynamics in Chronic Heart Failure Rats Induced by Doxorubicin

目的通过阿霉素(Dox)复制大鼠慢性心力衰竭(CHF)模型,观察Liguzinediol对CHF大鼠心功能的影响。方法通过血流动力学观察Liguzinediol对Dox(腹腔注射,2mg/kg)诱导的CHF大鼠左心室内压最大上升/下降速率(±dp/dtmax)、左心室内压(LVSP)、动脉收缩压(ASP)、动脉舒张压(ADP)和心率(HR)的变化;观察Liguzinediol对血清一氧化氮(NO)、一氧化氮合成酶(NOS)、超氧化物歧化酶(SOD)、肿瘤坏死因子?α(TNF?α)和白细胞介素-6(IL-6)以及血浆中丙二醛(MDA)的影响。结果 Liguzinediol能增加LVSP、+dp/dtmax、ASP、ADP、AP、HR,降低-dp/dtmax(P<0.05～0.01);降低NO、iNOS以及MDA的浓度,同时增强了SOD的活性(P<0.05～0.01);抑制IL-6和TNF?α的生成(P<0.05～0.01)。结论 Liguzinediol可明显改善Dox诱导的CHF大鼠血流动力学指标,减少模型大鼠炎症因子的释放以及抑制氧自由基的生成。

OBJECTIVE To explore the effect of Liguzinediol on cardiac function,ventricular remodeling and inflammation in chronic heart failure(CHF)rat model induced by doxorubicin(Dox).METHODS The hemodynamic changes in the maximum ascending/descending rate of left ventricular pressure(+dp/dtmax),left ventricular pressure(LVSP),arterial systolic pressure(ASP),arterial diastolic pressure(ADP)and heart rate(HR)were recorded by multichannel physiological recorder with intragastric administration of Liguzinediol in CHF rats induced by Dox(intraperitoneal injection,2 mg/kg).The effects of Liguzinediol on oxygen free radicals(NO,NOS,SOD,MDA)and inflammatory factors(IL-6 and TNF?α)were also detected by the kits.RESULTS Liguzinediol increased the levels of LVSP,+dp/dtmax,ASP,ADP,AP and HR,and decreased the level of-dp/dtmax(P<0.05,P<0.01).Liguzinediol decreased the concentration of NO,iNOS and MDA,increased the activity of SOD,and inhibited the contents of IL-6 and TNF?α(P<0.05,P<0.01).CONCLUSION Liguzinediol can improve ventricular remodeling by reducing the release of inflammatory factors,inhibiting the formation of oxygen free radicals.