摘要
真核生物中存在两种主要的非编码RNA(non codingRNA) ,在真核生物中发挥重要作用。一类为微小RNA(microRNA ,miRNA) ,另一为小干扰RNA(siRNA)。miRNA大小为 19～ 2 5nt,在体内与蛋白质形成核糖核蛋白复合体(miRNP) ,在真核基因的表达调控 ,生长发育中起重要作用。siRNA在RNA干扰 (RNAinterference ,RNAi)途径中起定位特异mRNA的作用。miRNA与siRNA有联系也有区别。
Two major kinds of non coding RNAs play important roles in eukaryotes.One is microRNA (miRNA),the other is small interference RNA (siRNA).miRNA,19～25 nt in length,fuctions in regulation of gene expression and development.Many kinds of miRNAs and some proteins assemble in a complex,miRNP,where miRNA gives its function.siRNA directs the target mRNA in RNA interference (RNAi).Some distinct differences are existed between miRNA and siRNA.The regulation mechanism of miRNA may be conserved in eukaryotes.
基金
国家自然基金 ( 3 992 80 0 6)
国家重大基础研究发展规划项目 (G2 0 0 0 0 162 0 5 )~~
