普瑞巴林联合吗啡缓释片治疗中重度癌性疼痛临床分析

Clinical analysis of lyrica combined morphine zyban in treatment of moderately severe cancer pain

目的对中重度癌性疼痛患者采用普瑞巴林联合吗啡缓释片治疗的效果进行探讨。方法选取我院2014-10-2015-10收治的90例癌性疼痛患者,随机分为观察组与对照组各45例,对照组采用口服吗啡缓释片治疗,观察组采用口服普瑞巴林联合吗啡缓释片治疗,对两组治疗7d后的疼痛缓解情况及不良反应发生率进行对比。结果在疼痛缓解率方面,观察组缓解率为95.6%,对照组为82.2%,差异有统计学意义,P<0.05;在不良反应发生率方面,观察组为31.1%,对照组为35.6%,差异无统计学意义,P>0.05。结论对中重度癌性疼痛患者采用普瑞巴林联合吗啡缓释片进行治疗,患者疼痛缓解情况明显,且不良反应较少,安全可靠,值得在临床中推广应用。

OBJECTIVE To explore the moderate and severe cancer pain were treated with pregabalin combined with morphine sustained-release tablets in the treatment effect.METHODS selected in our hospital during October October 2014 to 2015were 90 cases of cancer pain patients,were randomly divided into observation group and control group,45 cases in each.Patients in control group were treated with oral morphine sustained release tablets in the treatment,the observation group with oral pregabalin combined with morphine sustained release tablets in the treatment,of two groups after treatment for 7days of pain relief and adverse reaction incidence rate were compared.RESULTS the pain relief rate,the observation group remission rate was 95.6%,control group was 82.2%,the observation group was significantly higher than that of the control group,the difference is statistically significant,P<0.05;in the incidence of adverse reactions,the observation group was 31.1%,control group was 35.6%,the observation group,although lower than that of the control group,but the difference was not significant.No statistically significant(P>0.05).CONCLUSION in severe cancer pain patients by pregabalin combined with morphine sustained release tablets treatment,the pain relief is obvious and less adverse reaction,safe and reliable,it is worth in clinical application.