唾液SA、CEA测定在口腔鳞状细胞癌诊断中的意义

Significance of CEA and SA in saliva of patients with squamous cell carcinoma in oral and maxillofacial region

目的 通过对唾液中癌胚抗原 (CEA)和唾液酸 (SA)含量的测定和分析 ,探讨唾液中CEA和SA含量在口腔颌面部鳞状细胞癌诊断中的意义。方法 分别采用ELLISA法酶法 ,检测了 2 2例口腔鳞状细胞癌患者、2 2例口腔良性肿瘤患者、4 0例正常人唾液中的CEA和SA含量。结果 经过对测定数据进行统计学处理 ,SA含量在正常人组与良性肿瘤组对比 ,P >0 .0 5 ;正常人与鳞状细胞癌组对比 ,P <0 .0 1。良性肿瘤与鳞状细胞癌组对比 ,P >0 .0 5 ;CEA含量在正常人组与良性肿瘤和鳞状细胞癌组对比 ,P <0 .0 1,而鳞状细胞癌和良性组对比P >0 .0 5。结论 联合检测口腔颌面部鳞状细胞癌唾液CEA和SA含量明显高于正常人和良性肿瘤患者 ,口腔科临床开展唾液CEA和SA的测定 。

Objective To study the diagnostic value of carcinoembryonic antigen(CEA)and salic aside (SA)level in saliva of patients with malignant tumor.Methods ELISA method was adopted to detemine the SA level and ENZYMIC method was used to determine the CEA level in saliva of squamous cell carcinoma(SCC).22patients with SCC,22 patients with benign tumor and 40 normal adults.Results The results showed that SA and CEA in saliva of patients with oral and maxillofacial cancer were significantly higher than those of patients with benign and normal adults(P<0.01);also there were no diference in CEA and SA between the patients with benign tumor and normal adults (P>0.05).Conclusion CEA and SA level in sialiva of SCC group is much higher than those of benign tumor and normal group.CEA and SA in saliva used as tumor markes may play an assistant role for an early diagnosis of SCC in oral and maxillofacial region.