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Anticancer Activities of Substituted Cinnamic Acid Phenethyl Esters on Human Cancer Cell Lines 被引量:4

取代肉桂酸苯乙酯的抗肿瘤活性研究(英文)
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摘要 Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10 μmol·L -1 the lead compound CAPE possessed anticancer activities against human HL 60, Bel 7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel 7402 and Hela cell lines. Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10μmol·L^-1 the lead compmuM CAPE possessed anficancer activities against human HL-60, Bel-7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel-7402 and Hela cell lines.
出处 《Journal of Chinese Pharmaceutical Sciences》 CAS 2003年第4期184-187,共4页 中国药学(英文版)
基金 NationalScienceFoundationofChina(3 0 0 70 887)
关键词 medicinal chemistry cinnamic acid phenethyl esters chemical synthesis anticancer activity 苯乙烯酸 苯乙基酯 癌细胞 抗癌机制 化学合成 药物化学
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