摘要
Thirty-eight healthy female volunteers used a luteinizing hormone-releasing hormone agonist (LHRH-A) for inhibition of ovulation and contraception for 1 to 4 months.The potent agonist LHRH-A,(D-Ala^6,des-Gly-NH2^10)-LHRH ethylamide was administered intranasally in a daily dose of 0.5mg tp 10 women or 1.0mg to 28 women for 21 (Intermittent treatment group) or 30 days (Continuous treatment group).The treatment inhibited ovulation in all women during the 70 monthes of treatment.No pregnancies occurred during the treatment period in which no additional contraceptives were used.More significent menstruation disorders were observed in the continuous treatment group than that in the intermittent treatment group.There were no serious side effects.Ovulation occurred again promptly after the cessation of treatment even in women with amenorrhea during the period of treatment.The results suggest that the most appropriate dosage regimen for contraception by inhibition of ovulation in women was 0.5-1.0mg of LHRH-A/per day for 21 days.
