期刊文献+

Effect of low-intensity pulsed ultrasound on posterolateral lumbar fusion of rabbit 被引量:1

Effect of low-intensity pulsed ultrasound on posterolateral lumbar fusion of rabbit
下载PDF
导出
摘要 Objective:To observe the effect of low-intensity pulsed ultrasound in the posterolateral Lumbar fusion of rabbit.Methods:A total of 48 New Zealand white rabbits were randomly divided into the observation group and control group,including the autogenous iliac observation group.artificial bone observation group,artificial bone control group and autogenous iliac control group according to the different bone grafting.The posterolateral lumbar fusion of rabbits in each group was analyzed and compared.Results:After 4 weeks of treatment using the low-intensity pulsed ultrasound,the fusion in the bone grafting area of observation group was good.There was the relatively dense fusion area between the right transverse process and artificial bone.The left transverse process had been completely fused,with the clear bone trabecula through the fusion area.There was no significant fusion sign in the control group.According to the fusion comparison between two groups,the fusion rale of the observation group was 83.3%and it was significantly higher than the one of the control group(37.5%).Results of the comparison were statistically significant(P<0.05).The number of chondrocytes and the increase in the relative gray-scale in the fusion area of the iliac observation group were significantly higher than ones of the iliac control group(P<0.05).The number of chondrocytes and the increase in the relative gray-scale in the fusion area of the artificial bone observation group were significantly higher than ones of the artificial bone control group(P<0.05).The expression of IL-1.IL-6 and IL-17 4 weeks after the treatment of the observation group was significantly lower than the one of the control group,with the statistical significance(P<0.05).It indicated that the treatment of low-intensity pulsed ultrasound could reduce the expression level of inflammatory factors.Conclusions:The low-intensity pulsed ultrasound can significantly increase the bone grafting fusion rate of the rabbit's posterolateral lumbar fusion.The possible mechanism is that it promotes the lumbar posterolateral endochondral ossification and reduces the inflammatory reaction. Objective:To observe the effect of low-intensity pulsed ultrasound in the posterolateral Lumbar fusion of rabbit.Methods:A total of 48 New Zealand white rabbits were randomly divided into the observation group and control group,including the autogenous iliac observation group.artificial bone observation group,artificial bone control group and autogenous iliac control group according to the different bone grafting.The posterolateral lumbar fusion of rabbits in each group was analyzed and compared.Results:After 4 weeks of treatment using the low-intensity pulsed ultrasound,the fusion in the bone grafting area of observation group was good.There was the relatively dense fusion area between the right transverse process and artificial bone.The left transverse process had been completely fused,with the clear bone trabecula through the fusion area.There was no significant fusion sign in the control group.According to the fusion comparison between two groups,the fusion rale of the observation group was 83.3%and it was significantly higher than the one of the control group(37.5%).Results of the comparison were statistically significant(P&lt;0.05).The number of chondrocytes and the increase in the relative gray-scale in the fusion area of the iliac observation group were significantly higher than ones of the iliac control group(P&lt;0.05).The number of chondrocytes and the increase in the relative gray-scale in the fusion area of the artificial bone observation group were significantly higher than ones of the artificial bone control group(P&lt;0.05).The expression of IL-1.IL-6 and IL-17 4 weeks after the treatment of the observation group was significantly lower than the one of the control group,with the statistical significance(P&lt;0.05).It indicated that the treatment of low-intensity pulsed ultrasound could reduce the expression level of inflammatory factors.Conclusions:The low-intensity pulsed ultrasound can significantly increase the bone grafting fusion rate of the rabbit’s posterolateral lumbar fusion.The possible mechanism is that it promotes the lumbar posterolateral endochondral ossification and reduces the inflammatory reaction.
机构地区 [
出处 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2015年第1期68-72,共5页 亚太热带医药杂志(英文版)
关键词 Low-intensity PULSED ultrasound LUMBAR POSTEROLATERAL Fusion ILIUM Low-intensity pulsed ultrasound Lumbar posterolateral Fusion Ilium
  • 相关文献

参考文献14

  • 1王琪,苟三怀,刘岩,欧阳跃平,梁伟,韩庆林,王以进.低强度脉冲超声促进骨折愈合的生物力学实验研究[J].第二军医大学学报,2004,25(6):658-660. 被引量:7
  • 2Ki Hyoung Koo,Jae Hyup Lee,Bong‐Soon Chang,Choon‐Ki Lee.Effects of Alendronate on Lumbar Posterolateral Fusion Using Hydroxyapatite in Rabbits[J]. Artificial Organs . 2012 (12)
  • 3Gaoyi Wu,Lei Chen,Guoxiong Zhu,Yanliang Wang.Low-intensity ultrasound accelerates mandibular implant bone integration in dogs with mandibular osteoradionecrosis[J]. Journal of Surgical Research . 2012
  • 4Ki Hyoung Koo,Do Hyun Yeo,Jung Min Ahn,Byung‐Soo Kim,Chang‐Sung Kim,Gun‐Il Im.Lumbar Posterolateral Fusion Using Heparin‐Conjugated Fibrin for Sustained Delivery of Bone Morphogenic Protein‐2 in a Rabbit Model[J]. Artificial Organs . 2012 (7)
  • 5Robert McGuire,Leslie Pilcher,Joseph Dettori.Lumbar posterolateral fusion with local bone graft plus bone extender compared with iliac crest bone graft: a systematic review[J]. Evidence-Based Spine-Care Journal . 2011 (02)
  • 6Natalie M. Vaughan,James Grainger,Dan L. Bader,Martin M. Knight.The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures[J]. Medical & Biological Engineering & Computing . 2010 (12)
  • 7Takana Koshi,Seiji Ohtori,Gen Inoue,Toshinori Ito,Masaomi Yamashita,Kazuyo Yamauchi,Munetaka Suzuki,Yasuchika Aoki,Kazuhisa Takahashi.Lumbar posterolateral fusion inhibits sensory nerve ingrowth into punctured lumbar intervertebral discs and upregulation of CGRP immunoreactive DRG neuron innervating punctured discs in rats[J]. European Spine Journal . 2010 (4)
  • 8C. M. Korstjens,R. H. H. Rijt,G. H. R. Albers,C. M. Semeins,J. Klein-Nulend.Low-intensity pulsed ultrasound affects human articular chondrocytes in vitro[J]. Medical & Biological Engineering & Computing . 2008 (12)
  • 9Seiji Ohtori,Gen Inoue,Sumihisa Orita.Teriparatide Accelerates Lumbar Posterolateral Fusion in Women With Postmenopausal Osteoporosis Prospective Study. SPINE . 2012
  • 10Hwang Chang Ju,Vaccaro Alexander R,Hong Joseph,Lawrence James P,Fischgrund Jeffrey S,Alaoui-Ismaili Moulay Hicham,Falb Dean.Immunogenicity of osteogenic protein 1: results from a prospective, randomized, controlled, multicenter pivotal study of uninstrumented lumbar posterolateral fusion. Journal of neurosurgery. Spine . 2010

二级参考文献10

  • 1[1]Clinton R, Mark B,Ruaby JP,et al. The use of low-intensity ultrasound to accelerate the healing of fractures [J]. JBJS,2001,83A(2):259-270.
  • 2[4]Duarte LR. The stimulation of bone growth by ultrasound[J].Arch Orthop Trauma Surg,1983,101 (1): 153-159.
  • 3[5]Parvizi J,Parpura V,Greenleaf JF,et al. Calcium signaling is required for ultrasound-stimulated aggrecan synthesis by rat chondrocyt es [J]. J Orthop Res, 2002,20 (1): 51- 57.
  • 4[6]Ryaby JT, Mathew J, Duarte-Alves P. Low-intensity pulsed ultrasound affects adenylate cyclase activity and TGF-β synthesis in osteoblastic cells[J]. Trans Orthop Res Soc, 1992,7(3): 590-596.
  • 5[7]Rawool D, Goldberg B, Forsberg F, et al. Power Doppler assessment of vascular changes during fracture treatment with low-intensity ultrasound [J]. Trans Radiol Soc North Am,1998,83(6):1185-1196.
  • 6[8]Nolte PA, Klein NJ, Albers GH, et al. [ow-intensity ultrasound stimulates endochondral ossification in vitro[J]. J Orthop Res, 2001,19 (2): 301-307.
  • 7[9]Nishikori T,Ochi M,Uchio Y,et al. Effects of low-intensity pulsed ultrasound on proliferation and chondroitin sulfate synthesis of cultured chondrocytes embedded in atelocollagen gel[J]. J Biomed Mater Res, 2002,59(2): 201-206.
  • 8[10]Parvizi J, Wu CC, Lewallen DG, et al. Low-intensity ultrasound stimulates prosteoglycan synthesis in rat chondrocytes by increasing aggrecan gene expression [J]. J Orthop Res,1999,17(3) :488-494.
  • 9[11]Warden SJ, Favaloro JM, Bennell KL, et al. Low-intensity pulsed ultrasound stimulates a bone-forming response in UMR-106 cells[J]. Biochem Biophys Res Commun, 2001,286(3) :443-450.
  • 10汤荣光,罗建中,郑昱新,顾坚毅,王鹤岐.低强度超声波对骨折愈合中胶原代谢影响的实验研究[J].中国骨伤,2001,14(12):733-735. 被引量:7

共引文献7

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部