摘要
Objective: To investigate the diagnostic value and the relationship between the clinicopathological features and the levels of total and free prostate-specific antigen (PSA) in women with breast cancer.Methods: Using the microparticle enzyme immunoassay system, we measured the concentrations of these markers in the sera of 85 women with breast cancer and in 30 healthy women.Rseults: The lowest detection level for both markers was 0.01 ng/ml. Free PSA levels were significantly higher in women with breast cancer than that in healthy women (P<0.05). The percentage of free PSA predominant subjects was 37.6% in breast cancer patients and 3.3% in healthy women. Cut-off values were 0.36 ng/ml for total PSA and 0.02 ng/ml for free PSA. In women with breast cancer, total PSA positivity was 23.5% and free PSA positivity was 27.1%. Compared to negatives, total PSA positive patients had a higher percentage of lymph node involvement tumours (P>0.05). However, patients with predominant free PSA had a higher percentage of early stage than patients with predominant PSA-ACT.Conclusion: Although the sensitivity of free PSA predominance is low (37.6%) in distinguishing women with breast cancer from healthy women, its specificity is high (97.0%).Free PSA predominance tends to be present in early stage tumours. These findings may indicate clinical significance of preoperative measurement of serum total and free PSA in women with breast cancer.
目的 :检测术前乳腺癌患者血清中T PSA和F PSA的含量 ,探讨其和乳腺癌临床生物学行为的关系及在诊断中的价值。方法 :利用微粒子酶免分析法 ,检测 85名女性乳腺癌患者和 30名健康女性血清中T PSA和F PSA的含量。结果 :指标的最低检测值为 0 .0 1ng/ml。乳腺癌患者血清中F PSA水平明显高于健康女性 (P <0 .0 5 ) ,F PSA优势患者占 3.76 % ,而健康女性中仅占 3.3%。T PSA和F PSA的阳性判断值 (cut offvalue)分别为 0 .36ng/ml和0 .0 2ng/ml,女性乳腺癌患者的T PSA和F PSA阳性率分别为 2 3.5 %和 2 7.1%。T PSA阳性患者中 ,淋巴结转移者较多 (70 % ,P >0 .0 5 ) ,而F PSA优势患者中 ,早期 (Ⅰ、Ⅱ期 )发病率较高 (6 8.8% ,P >0 .0 5 )。结论 :虽然F PSA占优势鉴别乳腺癌的敏感性较低 ,但特异性较高。早期乳腺癌有F PSA占优势的趋势。血清检测T PSA和F
