摘要
利用混合淋巴细胞培养反应研究了灵芝多糖的免疫作用机理。结果表明培养12h,灵芝多糖(25,50,100,200μg/ml)可促进白细胞介素2的分泌,且具有剂量依赖关系。培养4d后,可增加总的细胞回收量以及Lyt 2^+和L3T4^+细胞的回收量。灵芝多糖还明显增强细胞毒T细胞的功能,在浓度为200μg/ml时,其杀伤活性增加100％。
Mixed lymphocyte response was used as a main model through all theexperiments In a series of concentrations (25, 50, 100, and 200μg/mi ), Ganodermapolysaccharides(GL- B) promoted the production of interleukin 2(IL- 2) in a concentra-tion- dependent manner after initiation of culture for 12 h and increased the total cell recoveryas well as that of Lyt 2^+ and L3T4^+ cells after 4 days of culture. The data also show thatthe polysaccharides markedly enhanced the cytotoxicity of cytotoxic T lymphocytes, which wasincreased by 100% at the concentration of 200 μg/ml.
出处
《药学学报》
CAS
CSCD
北大核心
1992年第5期331-335,共5页
Acta Pharmaceutica Sinica
基金
Project supported by the Fund of Chinese National Educational Commission,No.8910
关键词
灵芝
多糖
白细胞介素
T细胞亚群
Ganoderma lucidum
Polysaccharide
Mixed lymphocyte response MLR
Interleukin 2(IL--2)
T cell subpopulation
Cytotoxic T lymphocyte (CTL)
