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骨显像联合B-AKP测定评价^(89)Sr治疗前列腺癌骨转移疗效 被引量:5

Evaluation of Therapeutic Effects of Strontium-89 on Osseous Metastases of Prostate Cancer by Bone Scanning and B-AKP Measurement
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摘要 目的 :联合应用骨显像与骨型碱性磷酸酶 (B AKP)测定 ,对89Sr治疗前列腺癌骨转移疗效进行评价。 方法 :前列腺癌骨转移患者 73例 ,89Sr治疗前 1周及治疗后半年内进行全身骨显像及B AKP测定。①根据骨病灶数目骨显像分为 0、1、2、3共 4级 ,治疗前后病灶数目的变化采用配对t检验 ,骨显像各级别组间B AKP比较采用t检验。②计算病灶的摄取比值 (T/NT比值 ) ,其变化采用t检验。③治疗前后B AKP的变化采用t检验。 结果 :①治疗前骨转移病灶为 1~ 36 ( 8.6± 7.4 )个 ,共 6 18个 ,治疗后 0~ 34( 3.8± 6 .7)个 ,共 349个 ,明显减少 (t=4 .0 79,P<0 .0 1)。②治疗前T/NT值为 1.12~ 15 .38( 5 .36± 4 .6 7) ,治疗后为 1.2 8~ 16 .5 2 ( 3.17± 2 .95 ) ,降低显著 (t =7.90 7,P <0 .0 1)。③治疗前B AKP为 9.6~ 6 5 .5 ( 2 8.4± 14 .8) μg/L ,治疗后为10 .9~ 5 4 .7( 2 0 .9± 11.7) μg/L ,降低显著 (t=3.349,P <0 .0 0 2 )。④骨显像结合B AKP联合评估 ,ECT显像 5例假阳性与 6例假阴性得到纠正。 结论 :全身骨显像与B AKP测定有一定的互补性。89Sr治疗后疗效监测应以骨显像与B AKP测定结合进行 ,以准确评估疗效 。 Objective: To evaluate the therapeutic effects of strontium 89 on osseous metastases of prostate cancer by bone scanning and bone alkaline phosphatase(B AKP) measurement. Methods: One week before and within 6 months after strontium 89 therapy, bone scanning and B AKP measurement were performed in 73 patients with bone metastases of prostate cancer. ①According to the number of osseous lesions on bone imaging, the patients were divided into Grade 0, 1, 2 and 3, and the numbers of bone lesions before and after therapy were compared by t test. ②Tumor to non tumor ratios(T/NT) before and after treatment were calculated and compared. ③ Changes in B AKP before and after therapy were compared. Results: ①Among the 73 patients, bone scanning revealed 618 bone lesions, averaging 8.6 ± 7.4 before treatment. The number decreased to 349, averaging 3.8 ± 6.7 after treatment, which showed a significant reduction( t = 4.079 , P < 0.01 ). ②After therapy, T/NT of bone lesions decreased significantly( t = 7.907 , P < 0.01 ) from 5.36 ± 4.67 to 3.17 ± 2.95 . ③B AKP decreased significantly ( t = 3.349 , P < 0.002 ) from ( 28.4 ± 14.8 ) μg/L to ( 20.9 ± 11.7 ) μg/L. ④By bone scanning combined with B AKP measurement, 5 false positive cases and 6 false negative cases were corrected. Conclusion: There is certain complementarity between bone scanning and B AKP measurement, and they should be used in a combined way to achieve accurate evaluation of the therapeutic effects of strontium 89.
出处 《中华男科学杂志》 CAS CSCD 2004年第3期178-181,共4页 National Journal of Andrology
关键词 前列腺癌 骨转移瘤 ^89Sr全身骨显像 骨型碱性磷酸酶 疗效 治疗 prostate cancer osseous metastases strontium 89 bone scanning bone alkaline phosphatase therapeutic effect
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