2型糖尿病合并高血压患者血清NO、NOS水平的研究

Study on the NO and NOS level in the serum of patients with type 2 diabetes mellitus complicated with hypertension

目的 通过对 2型糖尿病 (2 - DM)合并高血压 (EH)患者血清一氧化氮 (NO)、一氧化氮合酶 (NOS)的测定 ,探讨其在 2 - DM合并 EH发生发展中的意义。方法 设正常对照组、单纯 2 - DM组和 2 - DM合并 EH组 ,分别测定血糖、胰岛素、血脂、NO及 NOS。结果 2 - DM合并 EH组空腹胰岛素 (FINS)、舒张压 (DBP)和收缩压 (SBP)等均显著高于单纯 2 - DM组和正常对照组 ;胰岛素敏感指数 (ISI)和 NO均显著低于其他两组。相关分析显示 NO与 FINS和血压呈明显负相关 ,与 ISI呈显著正相关。结论 血清中 NO含量与胰岛素抵抗和血压密切相关 ,2 - DM患者血清 NO水平的降低可能参与了 2 - DM患者合并 EH的发病。

Objective To study the significance of nitric oxide (NO) and nitric oxide synthase (NOS) in the occurrence and development of type 2 diabetes mellitus (DM) complicated with hypertension. Methods The subjects were divided into three groups: normal control group, simple type 2 diabetes mellitus group and type 2 diabetes mellitus complicated with hypertension group. Blood glucose, plasma lipids, insulin, NO and NOS were measured respectively. Results Compared with the simple diabetes mellitus group and normal control group, fasting insulin (FINS) and blood pressure were higher, insulin sensitivity index (ISI) and NO were lower in diabetes mellitus complicated with hypertension group. Related analysis indicated that NO was correlated negatively with NO, FINS and blood pressure, related positively with ISI. Conclusions The content of NO in serum was closely associated with insulin resistance (IR) and blood pressure, and the decrease of NO level in serum might be taken part in the occurrence of type 2 diabetes mellitus complicated with the hypertension.