冠心病患者血浆中抗热休克蛋白70抗体表达水平的研究

Levels of Plasma Antibodies to Heat-shock Protein 70 in Patients with Coronary Heart Disease

[目的 ]检测冠心病患者血浆中抗热休克蛋白 70 (HSP70 )抗体水平与正常人有无差异 ,并探讨其与冠心病发生发展之间的关系。 [方法 ]采用Western ELISA方法检测 192例冠心病患者中抗HSP70抗体水平 ,并以 192例无冠心病的个体作为对照。[结果 ] 192例冠心病患者中抗HSP70抗体阳性 7例 ,对照组 5例 ,病例组抗体阳性率与对照组之间差异无显著性 (P >0 .0 5 )。 [结论 ]本研究未发现抗HSP70抗体与冠心病的发生发展有联系 ,抗HSP70抗体在冠心病发病过程中的作用有待于进一步探讨。

To examine the level of plasma antibodies to heat-shock protein 70(HSP70) and evaluate their role in the progression of coronary heart disease. Western-ELISA method was used to examine the plasma levels of anti-HSP70 antibodies in 192 patients with coronary heart disease(CHD) and 192 controls. There were 7 positive in patients of the CHD group and 5 in the control group;there was no significant difference in the levels of anti-HSP70 antibodies was found between the two groups. [Conclusion] The anti-HSP70 antibodies are not related to the pathogenesis of coronary heart disease,however the role of anti-HSP70 antibodies in the development of coronary heart disease remains to be studied further.