乙肝病毒相关性肝病肝移植术后乙肝病毒再感染的防治

Prevention and treatment for reinfection of HBV after liver transplantation

目的 探讨联合应用拉米呋啶、乙肝免疫球蛋白预防肝移植术后乙肝病毒再感染的疗效。方法 回顾性研究 6例乙肝病毒相关终末期肝病患者肝移植术后联合应用拉米呋啶、乙肝免疫球蛋白的临床资料 ,分析总结该方案对预防肝移植术后乙肝病毒再感染的疗效。结果 1例于术后 3月内HBV DNA阳性 ,余 5例病毒检查阴性。结论 联合应用拉米呋啶。

Objective To investigate the effect of combined antiviral therapy with Lamivudine and HBIg on reinfection of hepatitis B virus (HBV) in orthotopic liver transplantation (OLT) recipients. Methods The clinical data of 6 liver transplantation recipients were analyzed retrospectively. Results Serum HBV DNA was positive in one recipient 3 month after liver transplantation, and other patients showed negative serum HBV. Conclusions Lamivudine combined with HBIg may be useful in preventing the reinfection of HBV after OLT.