无创迷走神经刺激在帕金森病中的研究进展

Research and Progress of Noninvasive Vagus Nerve Stimulation in Parkinson’s Disease

帕金森病(Parkinson’s disease, PD)是一种常见的神经系统疾病,其具有多种运动性和非运动性症状特征。药物治疗是现在治疗PD的主要方法,但常常也带来一些严重的副作用。因此,探究新的治疗方法,为治疗PD添砖加瓦是必要的。迷走神经刺激是一种新兴的神经调控技术,具有抗炎、神经保护的作用,这为PD的治疗提供了新思路。本综述总结了目前国内外迷走神经刺激在PD中的研究,其中重点放在了PD步态障碍的研究上。迷走神经具有改善冻结步态的作用,此外对PD病人的认知功能、吞咽功能、焦虑抑郁、胃肠道功能有潜在的治疗作用。

Parkinson’s disease is a common neurological disorder with a variety of motor and non-motor symptoms. Drug therapy is the main treatment for Parkinson’s disease, but it often comes with some serious side effects. Therefore, it is necessary to explore new therapeutic methods for the treatment of Parkinson’s disease. Vagus nerve stimulation is a new neuroregulatory technique with anti-inflammatory and neuroprotective effects, which provides a new idea for the treatment of Par-kinson’s disease. This review summarizes the current research on vagus nerve stimulation in Par-kinson’s disease at home and abroad, and focuses on gait disorders in Parkinson’s disease. Vagus nerve can improve frozen gait, and has potential therapeutic effect on cognitive function, swallowing function, anxiety and depression, gastrointestinal function in patients with Parkinson’s disease.