MTHFR (C677T)基因多态性与脑梗死风险因素及预后的相关性分析

Correlation Analysis between MTHFR (C677T) Gene Polymorphism and Risk Factors and Prognosis of Cerebral Infarction

目的:探究亚甲基四氢叶酸还原酶MTHFR (C677T)基因多态性与脑梗死风险因素及预后相关性,为脑梗死的二级预防及治疗提供理论支持。方法:选取2021年4月至2021年8月期间就诊于北华大学附属医院神经内科首发症状性脑梗死患者50例(男性39例,女性患者11例),平均年龄(66.6 ± 10.54)岁。以C677T基因型进行分组:野生型组(CC)、突变组(CT TT),收集患者一般资料、个人史、既往史、量表分数(NIHSS评分、Barthel指数)及症状复发。结果:1) 单因素分析结果显示在MTHFR (C677T)基因年龄、症状首发年龄、冠心病病史、糖尿病病史、吸烟史、饮酒史比较,差异无统计学意义(P > 0.05);2) 单因素分析结果显示MTHFR (C677T)基因多态性与脑梗死患者的性别、高血压、入院时严重程度、症状复发具有相关性,差异有统计学意义(P < 0.05);3) 在多变量分析结果显示MTHFR (C677T)是脑梗死复发的独立危险因素,CT TT基因型复发的概率是CC基因型的9.25倍,即MTHFR (C677T)基因突变时,脑梗死的复发率增高。结论:MTHFR (C677T)基因多态性与脑梗死的发生具有相关性,是脑梗死发生的独立危险因素。

Objective: To explore the correlation between MTHFR (C677T) gene polymorphism and risk factors and prognosis of cerebral infarction, and to provide theoretical support for secondary prevention and treatment of cerebral infarction. Methods: A total of 50 patients (39 males and 11 females) with an average age of (66.6 ± 10.54) were enrolled in the Department of Neurology, Affiliated Hospital of North China University from April to August 2021. Patients were divided into wild type group (CC) and mutant group (CT TT) with C677T genotype. General information, personal history, past history, scale score (NIHSS score, Barthel index) and symptom recurrence were collected. Results: 1) Univariate analysis showed no significant difference in MTHFR (C677T) gene age, age of first symptom onset, history of coronary heart disease, history of diabetes, smoking history and drinking history (P > 0.05). 2) The results of univariate analysis showed that MTHFR (C677T) gene polymorphism was associated with gender, hypertension, severity at admission and symptom recurrence of cerebral infarction patients, with statistical significance (P < 0.05). 3) Multivariate analysis showed that MTHFR (C677T) was an independent risk factor for cerebral infarction recurrence, and the recurrence probability of CT TT genotype was 9.25 times that of CC genotype, that is, the recurrence rate of cerebral infarction increased when MTHFR (C677T) gene was mutated. Conclusion: MTHFR (C677T) gene polymorphism is associated with the occurrence of cerebral infarction and is an independent risk factor for cerebral infarction.