呼吸道合胞病毒感染对气道菌群定位和免疫微环境的影响

Effect of Respiratory Syncytial Virus Infection on Airway Flora Localization and the Immune Microenvironment

呼吸道合胞病毒(RSV)是2岁以内儿童呼吸道感染的主要病原,尤其是小于6月的婴儿。目前针对RSV感染的治疗尚无特效治疗方法。婴儿生后呼吸道快速定植各种菌群,通过直接或间接的作用,对宿主健康有着重要影响。目前,RSV感染患儿其气道菌群变化及其局部的免疫微环境变化尚不完全清楚。因此本文针对RSV感染患儿其气道菌群变化和气道局部的免疫微环境变化进行概述性综述,期望从气道菌群角度对RSV防治提供一定的理论基础。

Respiratory syncytial virus (RSV) is the main cause of respiratory infections in children up to 2 years, especially in infants younger than 6 months. There is no specific treatment for RSV infection. The rapid colonization of various microflora in the respiratory tract of infants after birth has an important impact on host health through direct or indirect effects. At present, the changes in airway flora and local immune microenvironment in RSV-infected infants are not fully understood. Therefore, this paper provides an overview of the changes in airway flora and the local immune microenvironment in RSV-infected children, with the expectation that it would provide a theoretical basis for the prevention and treatment of RSV from the perspective of airway flora.