血管性认知障碍患者中miRNAs诊断价值的Meta分析

Meta-Analysis of the Diagnostic Value of miRNAs in Patients with Vascular Cognitive Impairment

目的:本研究使用meta分析探究miRNAs在血管性认知障碍患者中的诊断性能。方法:本研究采用Cochrane的方法进行Meta分析,检索的范围为从成立到2024年5月1日,数据库为PubMed,web of science,Embase,The Cochrane Library,中国知网、维普、万方。涵盖的范围为使用miRNAs诊断血管性认知障碍的诊断性试验,使用固定与随机效应模型分析汇总的敏感度(sensitivity, Sen)、特异度(specificity, Spe)、阳性似然比(positive likelihood ratio, PLR)、阴性似然比(negative likelihood ratio, NLR)、诊断比值比(diagnostic odd ratio, DOR)、SROC,并按地域与失调状态进行亚组分析。结果:共纳入8篇文献,1160名患者,19种不同类型的miRNAs,合并灵敏度为0.73,95% CI 0.71~0.74;合并特异性为0.77,95% CI 0.75~0.79;合并阳性似然比为3.26,95% CI 2.42~4.38;合并阴性似然比为0.33,95% CI 0.26~0.43;合并诊断比值比为10.64,95% CI 6.42~17.61,AUC为0.83。结论:本研究表明,miRNAs在诊断VCI中具有很高的准确性,可以作为VCI的潜在诊断标志物。Objective: This meta-analysis investigates the diagnostic performance of miRNAs in patients with vascular cognitive impairment (VCI). Methods: We conducted a meta-analysis following Cochrane methodology. Literature searches were performed up to May 1, 2024, using PubMed, Web of Science, Embase, The Cochrane Library, CNKI, VIP, and Wanfang databases. Studies assessing the diagnostic efficacy of miRNAs in VCI using sensitivity (Sen), specificity (Spe), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) were included. Subgroup analyses were conducted based on geographical regions and cognitive status. Results: Eight studies involving 1160 patients and examining 19 different types of miRNAs were included. The pooled sensitivity was 0.73 (95% CI 0.71~0.74), specificity was 0.77 (95% CI 0.75~0.79), positive likelihood ratio was 3.26 (95% CI 2.42~4.38), negative likelihood ratio was 0.33 (95% CI 0.26~0.43), diagnostic odds ratio was 10.64 (95% CI 6.42~17.61), and the SROC area under the curve was 0.83. Conclusion: This study demonstrates that miRNA profiles have high accuracy in diagnosing VCI and can serve as potential diagnostic biomarkers for VCI.