抗体偶联核酸药物的研究进展

Research Progress of Antibody-Oligonucleotide Conjugates

核酸药物具有不可替代优越性和应用局限性,基于抗体的递送系统已成为一种有效的治疗策略,因此将抗体和寡核苷酸结合以有效融合前者的组织特异性优势和后者的靶点特异性优势已成为新的发展趋势。本文旨在论述制备抗体偶联核酸药物的关键技术及各自优缺点,为抗体偶联核酸药物的发展提供研究思路。

Nucleic acid drugs have irreplaceable superiority and application limitations, and antibody has become an effective therapeutic strategy as the basis of delivery system. Therefore, the combination of antibody and oligonucleotide to effectively fuse the tissue-specific advantages of the former and the target-specific advantages of the latter has become a new development trend. This review aims to discuss the key techniques of preparing antibody-oligonucleotide conjugates, their benefits and drawbacks, and provide research ideas for the development of antibody-oligonucleotide conjugates.