摘要
Aim: Sub-Saharan Africa is undergoing an epidemiological transition responsible for a change in the metabolic profile in favour of insulin resistance. The aim of this study was to assess the dynamics of the prevalence of insulin resistance and associated risk factors in diabetic patients in the Democratic Republic of Congo between 2005 and 2023. Method: We measured fasting blood glucose and insulin levels and looked for metabolic syndrome parameters (2009 criteria) in type 2 diabetes patients in 2005-2008 (n = 176) and in 2018-2023 (n = 303). The HOMA model was used to measure insulin sensitivity and islet β-cell secretory function. Results: Between 2005 and 2013, the trend was towards an increase in the prevalence of insulin resistance (from 13.1% to 50.8%;p Conclusion: This present study shows an increase in insulin resistance in Congolese urban areas and a persistence of atypical diabetes mellitus in Congolese rural areas, confirming the particularity of the pathophysiology of the disease in African areas currently influenced by the epidemiological transition. Further studies using an appropriate methodology are required.
Aim: Sub-Saharan Africa is undergoing an epidemiological transition responsible for a change in the metabolic profile in favour of insulin resistance. The aim of this study was to assess the dynamics of the prevalence of insulin resistance and associated risk factors in diabetic patients in the Democratic Republic of Congo between 2005 and 2023. Method: We measured fasting blood glucose and insulin levels and looked for metabolic syndrome parameters (2009 criteria) in type 2 diabetes patients in 2005-2008 (n = 176) and in 2018-2023 (n = 303). The HOMA model was used to measure insulin sensitivity and islet β-cell secretory function. Results: Between 2005 and 2013, the trend was towards an increase in the prevalence of insulin resistance (from 13.1% to 50.8%;p Conclusion: This present study shows an increase in insulin resistance in Congolese urban areas and a persistence of atypical diabetes mellitus in Congolese rural areas, confirming the particularity of the pathophysiology of the disease in African areas currently influenced by the epidemiological transition. Further studies using an appropriate methodology are required.
作者
Dieudonné Masemo Bihehe
Ahadi Birindwa Bwihangane
Jean-Paulin Mukonkole Mbo
Christian Tshongo Muhindo
Michel Hermans
Philippe Bianga Katchunga
Dieudonné Masemo Bihehe;Ahadi Birindwa Bwihangane;Jean-Paulin Mukonkole Mbo;Christian Tshongo Muhindo;Michel Hermans;Philippe Bianga Katchunga(Hô,pital général de référence de Panzi, Faculté de Médecine, Université Evangélique en Afrique, Bukavu, DR Congo;Département de Médecine interne, Université de Kisangani, Provine de la Tshopo, DR Congo;Département de Médecine interne, Université Catholique de Bukavu, Bukavu, DR Congo;Service d’endocrinologie et de diabétologie, Cliniques universitaires Saint-Luc, Université Catholique de Louvain, Bruxelles, Belgique;Département de Médecine interne, Cliniques Universitaires de Bukavu, Université Officielle de Bukavu, Bukavu, DR Congo)